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Titolo:
CD10 antigen expression correlates with the t(14;18)(q32;q21) major breakpoint region in diffuse large B-cell lymphoma
Autore:
Fang, JM; Finn, WG; Hussong, JW; Goolsby, CL; Cubbon, AR; Variakojis, D;
Indirizzi:
Univ Michigan, Sch Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 an, Sch Med, Ann Arbor, MI 48109 USA Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Dept Pathol, Chicago, IL 60611 USA Univ Utah, Med Ctr, Salt Lake City, UT USA Univ Utah Salt Lake City UT USA iv Utah, Med Ctr, Salt Lake City, UT USA
Titolo Testata:
MODERN PATHOLOGY
fascicolo: 3, volume: 12, anno: 1999,
pagine: 295 - 300
SICI:
0893-3952(199903)12:3<295:CAECWT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMA; BCL-2 PROTEIN EXPRESSION; PROGNOSTIC-SIGNIFICANCE; FOLLICULAR LYMPHOMA; CHROMOSOMAL BREAKPOINT; CLINICAL-SIGNIFICANCE; GENE REARRANGEMENT; HIGH-GRADE; TRANSLOCATION; NEOPLASMS;
Keywords:
bcl-2; CD10; large cell lymphoma; t(14;18);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Finn, WG UnivMIichigan, Sch Med, Room M5242 Med Sci I,1301 Catherine Rd, Ann Arbor, Univ Michigan Room M5242 Med Sci I,1301 Catherine Rd Ann Arbor MIUSA 48109
Citazione:
J.M. Fang et al., "CD10 antigen expression correlates with the t(14;18)(q32;q21) major breakpoint region in diffuse large B-cell lymphoma", MOD PATHOL, 12(3), 1999, pp. 295-300

Abstract

Diffuse large B-cell lymphoma (DLBCL) is a common morphologic term for a biologically diverse group of lymphomas. The chromosome translocation, t(14;18)(q32;q21), and its associated bcl-2 gene rearrangement are generally associated with follicular lymphomas. Some investigators, however, proposed that the presence of the t(14;18) in DLBCL suggests a possible follicle center cell origin and might correlate with a higher relapse rate after therapy. The CD10 antigen is expressed in a majority of follicular lymphomas but isalso seen occasionally in DLBCLs. in this study, we examined 26 DLBCLs forCD10 expression by now cytometric analysis and tested them for the t(14;18)(q32;q21) major breakpoint region by a polymerase chain reaction-based method, bcl-2 protein expression was analyzed by an immunoperoxidase method. Of the 26 DLBCLs, 9 (35%) were CD10 positive, bcl-2 protein was expressed in7 (78%) of 9 CD10-positive cases and in 9 (53%) of 17 CD10-negative cases (P = .4). The t(14;18) translocation was present in 6 (67%) of 9 CD10-positive cases but in only 2 (17%) of 12 CD10-negative cases (P = .03). Five cases did not yield amplifiable DNA for analysis. In summary, no difference inbcl-2 protein expression was seen in CD10-positive versus CD10-negative DLBCLs, but CD10-positive DLBCLs were significantly more likely than CD10-negative DLBCLs to harbor the t(14;18) translocation. This suggests that CD10 might be a marker of follicle center cell origin in DLBCL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:04:37