Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Relationship between estrogen, serotonin, and depression
Autore:
Archer, JSM;
Indirizzi:
Med Univ S Carolina, Dept Obstet & Gynecol, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 col, Charleston, SC 29425 USA
Titolo Testata:
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
fascicolo: 1, volume: 6, anno: 1999,
pagine: 71 - 78
SICI:
1072-3714(199921)6:1<71:RBESAD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE REPLACEMENT THERAPY; POSTMENOPAUSAL WOMEN; IMIPRAMINE BINDING; PREMENSTRUAL-SYNDROME; FEMALE RAT; MENOPAUSE; SYMPTOMS; ESTRADIOL; MOOD; TRYPTOPHAN;
Keywords:
depression; peri- and postmenopausal women; serotonin; estrogen replacement therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Archer, JSM 1763 Orange Grove Shores Dr, Charleston, SC 29407 USA 1763 Orange Grove Shores Dr Charleston SC USA 29407 29407 USA
Citazione:
J.S.M. Archer, "Relationship between estrogen, serotonin, and depression", MENOPAUSE, 6(1), 1999, pp. 71-78

Abstract

Objective: A limited review of the medical literature was performed to determine whether there is an increase in the prevalence of depressive symptomatology in women undergoing menopause and whether this increase can be related to fluctuating levels of estrogen. In addition, we evaluate the possible effect that estrogen has on the concentrations of neurotransmitters, specifically serotonin, in the central nervous system and the subsequent impacton mood in peri- and postmenopausal women. Finally, we examine whether estrogen replacement therapy is efficacious in the treatment of depression during the climacteric. Design: Limited MEDLINE review of the medical literature on depression in women, the evidence for a serotonergic role in depression, evidence linkingestrogen to changes in serotonergic activity and evidence that estrogen therapy can improve depression. Results: Depression is more common in women than in men and seems to be increased at times of changing hormone levels in women. The serotonergic system seems to play a major role in depression, although other neurotransmitters are also involved. Estrogen can alter not just serotonergic activity butalso has an impact on the activity of several other neurotransmitters thatmight result in an antidepressant effect. At this time, estrogen therapy for the treatment of depression in peri- and postmenopausal women may be useful, but confirmatory studies are still lacking. Conclusions: There is suggestive evidence that estrogen therapy is appropriate treatment for mild-to-moderate depression in peri- and postmenopausal women. (Menopause 1999,6:71-78. (C) 1999, The North American Menopause Society.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:00:57