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Titolo:
Expression of the rat homologue of the Drosophila fat tumour suppressor gene
Autore:
Ponassi, M; Jacques, TS; Ciani, L; ffrench-Constant, C;
Indirizzi:
Wellcome CRC Inst Dev Biol & Canc, Cambridge CB2 1QR, England Wellcome CRCInst Dev Biol & Canc Cambridge England CB2 1QR 1QR, England Univ Cambridge, Dept Med Genet, Cambridge, England Univ Cambridge Cambridge England ge, Dept Med Genet, Cambridge, England Adv Biotechnol Ctr, Cell Biol Lab, I-16132 Genoa, Italy Adv Biotechnol Ctr Genoa Italy I-16132 ll Biol Lab, I-16132 Genoa, Italy Univndorvie Site, Cambridge Ctr Brain Repair, MRC, Cambridge CB2 2QQ, Engla Univ Forvie Site Cambridge England CB2 2QQ MRC, Cambridge CB2 2QQ, Engla
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 2, volume: 80, anno: 1999,
pagine: 207 - 212
SICI:
0925-4773(199902)80:2<207:EOTRHO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CADHERIN; ASTROCYTES; MEMBRANE; ENCODES; TISSUE; CELLS;
Keywords:
protocadherin; fat; cadherin; tumour suppressor; neuroepithelium; embryo; epithelium; neural stem cell; neurosphere; ventricular zone; subventricular zone; EGF repeat; laminin A-G domain; PDZ domain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: ffrench-Constant, C WellcomeandC Inst Dev Biol & Canc, Tennis Court Rd, Cambridge CB2 1QR, Engl Wellcome CRC Inst Dev Biol & Canc Tennis Court Rd Cambridge England CB2 1QR
Citazione:
M. Ponassi et al., "Expression of the rat homologue of the Drosophila fat tumour suppressor gene", MECH DEVEL, 80(2), 1999, pp. 207-212

Abstract

We have sequenced and defined the expression during rat embryogenesis of the protocadherin fat, the murine homologue of a Drosophila tumour suppressor gene. As previously described for human fat, the sequence encodes a largeprotocadherin with 34 cadherin repeats, five epidermal growth factor (EGF)-like repeats containing a single laminin A-G domain and a putative transmembrane portion followed by a cytoplasmic sequence. This cytoplasmic sequence shows homology to the beta-catenin binding regions of classical cadherin cytoplasmic tails and also ends with a PDZ domain-binding motif, In situ hybridization studies at E15 show that fat is predominately expressed in fetal epithelial cell layers and in the CNS, although expression is also seen in tongue musculature and condensing cartilage. Within the CNS, expression is seen in the germinal regions and in areas of developing cortex, and this neural expression pattern is also seen at later embryonic (E18) and postnatal stages. No labelling was seen in adult tissues except in the CNS, where the remnant of the germinal zones, as well as the dentate gyrus, continue to express fat. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 18:02:27