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Titolo:
Expression of growth/differentiation factor 11, a new member of the BMP/TGF beta superfamily during mouse embryogenesis
Autore:
Nakashima, M; Toyono, T; Akamine, A; Joyner, A;
Indirizzi:
KyushunUniv, Fac Dent, Dept Operat Dent & Endodontol, Fukuoka 8128582, Japa Kyushu Univ Fukuoka Japan 8128582 nt & Endodontol, Fukuoka 8128582, Japa Kyushu128582,Grad Sch Genet Resources Technol, Lab Mol Gene Tech, Fukuoka 8 Kyushu Univ Fukuoka Japan 8128582 Technol, Lab Mol Gene Tech, Fukuoka 8 Howard Hughes Med Inst, New York, NY USA Howard Hughes Med Inst New York NY USA Hughes Med Inst, New York, NY USA NYU, Med Ctr, Dept Cell Biol, New York, NY 10016 USA NYU New York NY USA 10016 Med Ctr, Dept Cell Biol, New York, NY 10016 USA NYU, Med Ctr, Dept Physiol & Neurosci, New York, NY 10016 USA NYU New York NY USA 10016 Dept Physiol & Neurosci, New York, NY 10016 USA
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 2, volume: 80, anno: 1999,
pagine: 185 - 189
SICI:
0925-4773(199902)80:2<185:EOGF1A>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE MORPHOGENETIC PROTEINS; MICE;
Keywords:
TGF beta superfamily; bone morphogenetic protein; activin/inhibin; growth/differentiation factor; embryogenesis; dental pulp; tooth development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Nakashima, M Care,of Joyner A, NYU Med Ctr, Skirball Inst Biomol Med, DeptGenet Program Care of Joyner A 540 1st Ave New York NY USA 10016 et Program
Citazione:
M. Nakashima et al., "Expression of growth/differentiation factor 11, a new member of the BMP/TGF beta superfamily during mouse embryogenesis", MECH DEVEL, 80(2), 1999, pp. 185-189

Abstract

We have cloned and characterized a new member of the bone morphogenetic protein/transforming growth factor beta (BMP/TGF beta) superfamily, growth differentiation factor 11 (Gdf11), from rat incisor pulp RNA by reverse transcription-polymerase chain reaction using degenerate primers. The mature carboxyl-terminal domain encoded by Gdf11 is most closely related to Gdf8, being 90% identical to the mouse gene. Northern blot analysis revealed Gdf11 is expressed in adult dental pulp and brain. In situ hybridization of sections and whole-mount embryos demonstrated Gdf11 is first strongly expressed in restricted domains at 8.5 days post coitus (dpc) when it is highest in the tail bud. At 10.5 dpc, it is expressed in the branchial arches, limb bud,tail bud and posterior dorsal neural tube. Later, it is expressed in terminally-differentiated odontoblasts, the nasal epithelium, retina and specific regions of the brain. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 18:59:49