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Titolo:
Human immunodeficiency virus type 1 derived from cocultures of immature dendritic cells with autologous T cells carries T-cell-specific molecules on its surface and is highly infectious
Autore:
Frank, I; Kacani, L; Stoiber, H; Stossel, H; Spruth, M; Steindl, F; Romani, N; Dierich, MP;
Indirizzi:
Innsbruck Univ, Inst Hyg, Innsbruck, Austria Innsbruck Univ Innsbruck Austria uck Univ, Inst Hyg, Innsbruck, Austria Innsbruck Univ, Ludwig Boltzman Inst AIDS Res, Innsbruck, Austria Innsbruck Univ Innsbruck Austria zman Inst AIDS Res, Innsbruck, Austria Innsbruck Univ, Dept Dermatol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 matol, A-6020 Innsbruck, Austria Agr Univ Vienna, Inst Appl Microbiol, A-1180 Vienna, Austria Agr Univ Vienna Vienna Austria A-1180 Microbiol, A-1180 Vienna, Austria
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 4, volume: 73, anno: 1999,
pagine: 3449 - 3454
SICI:
0022-538X(199904)73:4<3449:HIVT1D>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIV-1 INFECTION; PRODUCTIVE INFECTION; BLOOD MONOCYTES; ANTIGEN; REPLICATION; DIFFERENTIATION; ACQUISITION; GENERATION; SYNCYTIA; PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Dierich, MP Leopoldtrianzens Univ, Inst Hyg, Fritz Pregl Str 3-3, A-6020 Innsbruck, Aus Leopold Franzens Univ Fritz Pregl Str 3-3 Innsbruck Austria A-6020
Citazione:
I. Frank et al., "Human immunodeficiency virus type 1 derived from cocultures of immature dendritic cells with autologous T cells carries T-cell-specific molecules on its surface and is highly infectious", J VIROLOGY, 73(4), 1999, pp. 3449-3454

Abstract

During the budding process, human immunodeficiency virus type 1 (HIV-1) acquires cell surface molecules; thus, the viral surface of HIV-1 reflects the antigenic pattern of the host cell. To determine the source of HIV-1 released from cocultures of dendritic cells (DC) with T cells, immature DC (imDC), mature DC (mDC), T cells, and their cocultures were infected with different HIV-1 isolates. The macrophage-tropic HIV-1 isolate Ba-L allowed viralreplication in both imDC and mDC, whereas the T-cell-line-tropic primary isolate PI21 replicated in mDC only. By a virus capture assay, HIV-1 was shown to carry a T-cell- or DC-specific cell surface pattern after production by T cells or DC, respectively. Upon cocultivation of HIV-1-pulsed DC with T cells, HIV-1 exclusively displayed a typical T-cell pattern. Additionally, functional analysis revealed that HIV-1 released from imDC-T-cell cocultures was more infectious than HIV-1 derived from mDC-T-cell cocultures and from cultures of DC, T cells, or peripheral blood mononuclear cells alone. Therefore, we conclude that the interaction of HIV-1-pulsed imDC with T cells in vivo might generate highly infectious virus which primarily originatesfrom T cells.

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Documento generato il 27/11/20 alle ore 22:30:28