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Titolo:
Role of nitric oxide in restenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit: Effects on neointimal hyperplasia and vascular remodeling
Autore:
Le Tourneau, T; Van Belle, E; Corseaux, D; Vallet, B; Lebuffe, G; Dupuis, B; Lablanche, JM; McFadden, E; Bauters, C; Bertrand, ME;
Indirizzi:
Univ Lille, Lille, France Univ Lille Lille FranceUniv Lille, Lille, France CHRU, Lille, France CHRU Lille FranceCHRU, Lille, France
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 3, volume: 33, anno: 1999,
pagine: 876 - 882
SICI:
0735-1097(19990301)33:3<876:RONOIR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; SERIAL INTRAVASCULAR ULTRASOUND; INTIMAL HYPERPLASIA; L-ARGININE; CORONARY ANGIOPLASTY; ARTERIAL INJURY; EXPERIMENTAL ATHEROSCLEROSIS; CELLULAR PROLIFERATION; CAROTID-ARTERY; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bauters, C Hop Cardiol, Serv Cardiol B, Blvd Prof J Leclercq, F-59037 Lille, France Hop Cardiol Blvd Prof J Leclercq Lille France F-59037 , France
Citazione:
T. Le Tourneau et al., "Role of nitric oxide in restenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit: Effects on neointimal hyperplasia and vascular remodeling", J AM COL C, 33(3), 1999, pp. 876-882

Abstract

OBJECTIVES The purpose of this study was to assess the effects of L-arginine and NG-nitro-L-arginine methyl ester (L-NAME) on neointimal hyperplasia and vascular remodeling after balloon angioplasty in the hypercholesterolemic rabbit;BACKGROUND Restenosis after balloon angioplasty is a consequence of both neointimal hyperplasia and vessel remodeling. Nitric oxide inhibits neointimal hyperplasia, but its effect on vessel remodeling is unknown. METHODS Six weeks after induction of bilateral iliac atherosclerosis, 48 rabbits underwent successful angioplasty in 75 vessels. Eight rabbits (acutegroup) were sacrificed immediately after angioplasty. The remaining animals received either placebo (chronic control group), or a diet supplemented with either L-arginine (1.5 g/kg/day), or L-NAME (15 mg/kg/day) for 4 weeks after angioplasty. RESULTS The intimal area was significantly greater in the chronic control group compared to the acute group (2.60 +/- 1.03 mm(2) vs. 1.35 +/- 0.62 mm(2)). This increase in intimal area was lower in the L-arginine group (1.79+/- 0.61 mm(2)), and greater in the L-NAME group (3.23 +/- 0.92 mm(2)). The area circumscribed by the internal elastic lamina (IEL) increased significantly in the control group compared to the acute group (from 2.52 +/- 0.66to 3.33 +/- 0.85 mm(2)); a more marked increase occurred in the L-NAME group (3.90 +/- 0.85 mm(2)). By contrast; IEL area was unchanged in the L-arginine group (2.41 +/- 0.62 mm(2)). As a result, there was no significant difference in lumen area after 4 weeks in the chronic groups (control: 0.74 +/- 0.38 mm(2); L-arginine: 0.50 +/- 0.43 mm(2); L-NAME: 0.48 +/- 0.42 mm(2)). CONCLUSIONS Our results demonstrate that L-arginine inhibits whereas L-NAME stimulates neointimal hyperplasia after experimental balloon angioplasty in the hypercholesterolemic rabbit. However, the lack of vessel enlargementin the L-arginine group resulted in a similar final lumen size in the L-NAME and L-arginine groups. (C) 1999 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:01:53