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Titolo:
THE INFLUENCE OF THE ANTIANDROGEN FLUTAMIDE ON EARLY SEXUAL-DIFFERENTIATION OF THE MARSUPIAL MALE
Autore:
LUCAS JC; RENFREE MB; SHAW G; BUTLER CM;
Indirizzi:
UNIV MELBOURNE,DEPT ZOOL PARKVILLE VIC 3052 AUSTRALIA UNIV MELBOURNE,DEPT ZOOL PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
Journal of Reproduction and Fertility
fascicolo: 2, volume: 109, anno: 1997,
pagine: 205 - 212
SICI:
0022-4251(1997)109:2<205:TIOTAF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTICULAR DESCENT; HORMONAL-CONTROL; RAT PROSTATE; TAMMAR WALLABY; CRYPTORCHIDISM; FEMINIZATION; GLANDS; GROWTH; AXIS; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Lucas et al., "THE INFLUENCE OF THE ANTIANDROGEN FLUTAMIDE ON EARLY SEXUAL-DIFFERENTIATION OF THE MARSUPIAL MALE", Journal of Reproduction and Fertility, 109(2), 1997, pp. 205-212

Abstract

The development of the prostate and the normal descent of the testes in the tammar wallaby (Macropus eugenii) were influenced by treatment with the non-steroidal anti-androgen flutamide. Male pouch young were treated daily from day 9 to day 45, or from day 20 to day 45, of pouchlife. Prostate development was inhibited in both treatment groups to a similar extent. Since prostatic buds do not form until day 25 of pouch life, these results suggest that there is a window of androgen sensitivity operating between day 20 and day 25 of pouch life. The number of prostatic buds was significantly lower, but despite the duration oftreatment there was never complete abolition of prostate development. Although testes had descended to the same position in treated and control pouch young, inguinal hernias developed in three of four animals treated with flutamide from day 9. These data demonstrate that virilization of the male reproductive tract in this marsupial is dependent ona relatively brief exposure to androgens. Blocking androgen receptor action interferes with normal development ol: the inguinal canal, which suggests that it is this aspect of inguinoscrotal testicular descentthat is androgen dependent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:35:37