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Titolo:
Effects of acute tryptophan depletion on plasma and cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in normal volunteers
Autore:
Williams, WA; Shoaf, SE; Hommer, D; Rawlings, R; Linnoila, M;
Indirizzi:
NIAAA, LCS, NIH, Bethesda, MD 20892 USA NIAAA Bethesda MD USA 20892NIAAA, LCS, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 4, volume: 72, anno: 1999,
pagine: 1641 - 1647
SICI:
0022-3042(199904)72:4<1641:EOATDO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; SEROTONIN REUPTAKE INHIBITORS; HEALTHY-VOLUNTEERS; BRAIN TRYPTOPHAN; RAPID DEPLETION; ANTIDEPRESSANT ACTION; RAT HIPPOCAMPUS; NORMAL MALES; FREE DIET; RELEASE;
Keywords:
serotonin; CSF; tryptophan; depletion; plasma; 5-hydroxyindoleacetic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, WA NIAAA, LCS, NIH, Bldg 10,Room 6S240,10 Ctr Dr, Bethesda, MD 20892 USA NIAAA Bldg 10,Room 6S240,10 Ctr Dr Bethesda MD USA 20892 USA
Citazione:
W.A. Williams et al., "Effects of acute tryptophan depletion on plasma and cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in normal volunteers", J NEUROCHEM, 72(4), 1999, pp. 1641-1647

Abstract

Brain serotonin synthesis and metabolism (turnover), as indicated by CSF concentrations of 5-hydroxyindoleacetic acid (5-HIAA), may depend on plasma concentrations of the essential amino acid L-tryptophan (TRP). We investigated the biochemical effects of acute plasma TRP depletion (ATD) in normal volunteers undergoing a 36-h CSF collection via lumbar drain. Six subjects who were in good health were put on a low-TRP diet (160 mg/day) 24 h before lumbar puncture; this diet was continued for the first 22 h of the CSF collection. At hour 22, subjects ingested a TRP-deficient 15-amino acid drink shown previously to deplete plasma TRP. Total plasma TRP, free plasma TRP, and CSF TRP subsequently decreased 86.3, 86.5, and 92.3%, respectively. CSF 5-HIAA decreased by 32.8%. Plasma total and free TRP concentrations were both decreased at similar to 2 h following ingestion of the TRP-free amino acid drink and were lowest similar to 6 h after ATD; CSF TRP and 5-HIAA were decreased at 2.5 h and similar to 4 h after ATD, respectively. CSF TRP was lowest 8.0 h later. CSF 5-HIAA continued to decrease 14 h after the TRP-deficient amino acid drink was given.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:30:00