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Titolo:
Fyn tyrosine kinase reduces the ethanol inhibition of recombinant NR1/NR2Abut not NR1/NR2B NMDA receptors expressed in HEK 293 cells
Autore:
Anders, DL; Blevins, T; Sutton, G; Swope, S; Chandler, LJ; Woodward, JJ;
Indirizzi:
Virginiachmond,wealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Ri Virginia Commonwealth Univ Richmond VA USA 23298 Pharmacol & Toxicol, Ri Louisiana State Univ, Med Ctr, Dept Pharmacol, Shreveport, LA USA Louisiana State Univ Shreveport LA USA ept Pharmacol, Shreveport, LA USA Georgetown,Univ, Med Ctr, Georgetown Inst Cognit & Computat Sci, Washington Georgetown Univ Washington DC USA 20007 Cognit & Computat Sci, Washington
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 4, volume: 72, anno: 1999,
pagine: 1389 - 1393
SICI:
0022-3042(199904)72:4<1389:FTKRTE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTORS; SENSITIVITY; CHANNELS; NEURONS;
Keywords:
Fyn tyrosine kinase; ethanol; NMDA receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Anders, DL VirginiaxCommonwealth Univ, Med Coll Virginia, Dept Pharmacol &Toxicol, Bo Virginia Commonwealth Univ Box 980524 Richmond VA USA 23298 Bo
Citazione:
D.L. Anders et al., "Fyn tyrosine kinase reduces the ethanol inhibition of recombinant NR1/NR2Abut not NR1/NR2B NMDA receptors expressed in HEK 293 cells", J NEUROCHEM, 72(4), 1999, pp. 1389-1393

Abstract

NMDA receptors are potentiated by phosphorylation in a subunit- and kinase-specific manner. Both native and recombinant NMDA receptors are inhibited by behaviorally relevant concentrations of ethanol, Whether the phosphorylation state of individual subunits modulates the ethanol sensitivity of these receptors is not known. In this study, the effects of Fyn tyrosine kinaseon the ethanol sensitivity of specific recombinant NMDA receptors expressed in HEK 293 cells were investigated. Whole-cell mode patch clamp and ratiometric calcium imaging demonstrated that the degree of ethanol inhibition of NR1/NR2B receptors was unaffected by Fyn tyrosine kinase. In contrast, the inhibition of NR1/NR2A receptors by ethanol (100 mM) was significantly reduced under conditions of enhanced Fyn-mediated tyrosine phosphorylation ofthe NR2A subunit. This effect was not observed at lower concentrations of ethanol (less than or equal to 50 mM). These results suggest that tyrosine phosphorylation of specific NMDA receptors by Fyn tyrosine kinase may regulate the sensitivity of these receptors to the sedative/hypnotic concentrations of ethanol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:17:45