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Titolo:
Lipase-catalysed alkoxycarbonylation of thymidine: influence of the carbonate on the regioselectivity of the process
Autore:
Garcia-Alles, LF; Gotor, V;
Indirizzi:
Univ Oviedo, Fac Quim, Dept Quim Organ & Inorgan, E-33071 Oviedo, Spain Univ Oviedo Oviedo Spain E-33071 Organ & Inorgan, E-33071 Oviedo, Spain
Titolo Testata:
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
fascicolo: 4, volume: 6, anno: 1999,
pagine: 407 - 410
SICI:
1381-1177(19990402)6:4<407:LAOTIO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DERIVATIVES;
Keywords:
enzymes; alkoxycarbonylation; thymidine; organic solvents; regioselectivity; mechanism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Gotor, V Univ Oviedo, Fac Quim, Dept Quim Organ & Inorgan, E-33071 Oviedo,Spain Univ Oviedo Oviedo Spain E-33071 Inorgan, E-33071 Oviedo, Spain
Citazione:
L.F. Garcia-Alles e V. Gotor, "Lipase-catalysed alkoxycarbonylation of thymidine: influence of the carbonate on the regioselectivity of the process", J MOL CAT B, 6(4), 1999, pp. 407-410

Abstract

Serine-hydrolases are known to catalyse alkoxycarbonylation processes. In the field of nucleoside chemistry they can be used to perform regioselective transformations at the carbohydrate frame. In this paper we present data regarding the influence of the structure of the carbonate on the regioselectivity of the alkoxycarbonylation of thymidine catalysed by Candida antarctica lipase. As expected, assuming the formation of an acyl-enzyme intermediate, the structure of the leaving group portion of the carbonate has no effect, whereas the remaining alcoholic portion of the carbonate has a marked effect. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:31:25