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Titolo:
Epidemiology of cancer of the large bowel - The 12-year experience of a specialized registry in Northern Italy
Autore:
de Leon, MP; Benatti, P; Percesepe, A; Di Gregorio, C; Fante, R; Losi, L; Rossi, G; Pedroni, M; Roncucci, L;
Indirizzi:
Univ Modena, Dept Internal Med, I-41100 Modena, Italy Univ Modena ModenaItaly I-41100 ept Internal Med, I-41100 Modena, Italy Univ Modena, Dept Morphol Sci, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 Dept Morphol Sci, I-41100 Modena, Italy Osped di Carpi, Div Pathol, Modena, Italy Osped di Carpi Modena ItalyOsped di Carpi, Div Pathol, Modena, Italy Osped di Mantova, Div Pathol, Mantova, Italy Osped di Mantova Mantova Italy d di Mantova, Div Pathol, Mantova, Italy
Titolo Testata:
ITALIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
fascicolo: 1, volume: 31, anno: 1999,
pagine: 10 - 18
SICI:
1125-8055(199901/02)31:1<10:EOCOTL>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPOLYPOSIS COLORECTAL-CANCER; FAMILIAL AGGREGATION; GENERAL-POPULATION; 3-YEAR EXPERIENCE; COLON-CANCER; CARCINOMA; SURVIVAL; TUMORS; MORTALITY; MUTATIONS;
Keywords:
cancer; colon; rectum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: de Leon, MP Policlin,Modena, Dipartimento Med Interna, Via del Pozzo 71, I-41100 Modena Policlin Modena Via del Pozzo 71 Modena Italy I-41100 Modena
Citazione:
M.P. de Leon et al., "Epidemiology of cancer of the large bowel - The 12-year experience of a specialized registry in Northern Italy", ITAL J GAST, 31(1), 1999, pp. 10-18

Abstract

Background. In 1984 a specialized colorectal cancer registry was instituted in Modena; aims of the Registry were: the evaluation of incidence and mortality, the study of morphological aspects, staging, staging and familiarity of the registered patients. Aims. Purpose of the research was to provide an updated description of themain findings (in particular incidence, staging, morphology and survival) observed in the 12-year registration period. Patients and methods. Between January 1984 and December 1995, 1,899 malignancies of the large bowel in 1,831 patients were registered. Tumours were classified according to the International Classification of the Diseases forOncology (ICD-O) and staged with the TNM system Cancer specific srm il nl was assessed with life table analysis and Log-Rank tests. Results. Crude incidence rare showed minor fluctuations between 1984 and 1989, but tended to rise in the following pears. Tumours were mostly locateddistal to the splenic flexure (73.3% of the total), with a slight tendencyover time to a gradual "shift" to the right colon. Staging became progressively more favourable throughout the registration; in 1984 both stages I, II and stage IV + unstaged lesions represented 40% of the total, but in 1995the former rose to 50% whereas the latter fell to 21.6% (p<0.001). This more to earlier stages resulted in an improved survival of patients registered in 1990-91 versus 1983-85 (Log-Rank 14.3 p<0.002). Factors associated with a poor survival were the advanced age of patients at diagnosis (>74) and clinical stage. Conclusions. Main aspects of the investigation were the increasing crude incidence rates of colorectal turnovers and the gradual increase of neoplasms diagnosed irt a more favourable staging. It is like likely that the improvement of staging and survival observed in the 12 fears of registration canbe attributed to the improved attitude to health care of the population, and possibly to the improvement of surgical techniques.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:56:46