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Titolo:
Haemophilic arthropathy resembles degenerative rather than inflammatory joint disease
Autore:
Roosendaal, G; van Rinsum, AC; Vianen, ME; van den Berg, HM; Lafeber, FPJG; Bijlsma, JWJ;
Indirizzi:
Univt,ed Ctr Utrecht, Van Creveld Clin, Div Internal Med, NL-3508 GA Utrech Univ Med Ctr Utrecht Utrecht Netherlands NL-3508 GA d, NL-3508 GA Utrech Univ Med Ctr Utrecht, Dept Rheumatol, NL-3508 GA Utrecht, Netherlands UnivMed Ctr Utrecht Utrecht Netherlands NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Clin Immunol, NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht Utrecht Netherlands NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Orthopaed Surg, NL-3508 GA Utrecht, NetherlandsUniv Med Ctr Utrecht Utrecht Netherlands NL-3508 GA Utrecht, Netherlands
Titolo Testata:
HISTOPATHOLOGY
fascicolo: 2, volume: 34, anno: 1999,
pagine: 144 - 153
SICI:
0309-0167(199902)34:2<144:HARDRT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE HEMOPHILIA-A; OSTEOARTHRITIC CARTILAGE; RHEUMATOID DISEASE; CULTURE; PATHOGENESIS; MANAGEMENT; SYNOVITIS; ARTHRITIS; IRON;
Keywords:
haemophilia; haemophilic arthropathy; osteoarthritis; rheumatoid arthritis; cartilage; synovium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Roosendaal, G Univ8Med Ctr Utrecht, Van Creveld Clin, Div Internal Med, POB 85500, NL-350 Univ Med Ctr Utrecht POB 85500 Utrecht Netherlands NL-3508GA
Citazione:
G. Roosendaal et al., "Haemophilic arthropathy resembles degenerative rather than inflammatory joint disease", HISTOPATHOL, 34(2), 1999, pp. 144-153

Abstract

Aims: To investigate the pathogenetic mechanisms of haemophilic arthropathy (HA) by comparing end-stage arthropathy with osteoarthritis (OA: a degenerative joint disorder) and rheumatoid arthritis (RA: an inflammation-mediated joint disease),Methods and results: Cartilage and synovium from patients with HA (n=10), RA (n=8), OA (n=14) and normal control subjects (n=6) were examined morphologically, biochemically and histochemically, Cartilage in RA exhibited characteristics of degenerative joint disease (OA), as evidenced by morphological, histochemical (Safranin-O Fast green-iron haematoxylin, Mankin grade) and biochemical (proteoglycan synthesis, glycosaminoglycan content and DNA content) changes, whereas synovium in HA showed characteristics of inflammation-mediated joint disease (RA), as evidenced by histochemical (inflammation haematoxylin and eosin (H&E) and iron deposition, Perls' blue) and biochemical changes (interleukin (IL)-1, IL-6, tumour necrosis factor (TNF)alpha and catabolic properties). Conclusion: Haemophilic arthropathy shows characteristics of both inflammatory and degenerative joint disease. On the basis of these results and published information, it appears that degenerative cartilage changes have a dominant role in HA and are augmented by relatively mild inflammation of the synovium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:28:06