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Titolo:
Cross-linking of the B cell receptor induces activation of phospholipase Dthrough Syk, Btk and phospholipase C-gamma 2
Autore:
Hitomi, T; Yanagi, S; Inatome, R; Yamamura, H;
Indirizzi:
Kobe Univ, Sch Med, Dept Biochem, Chuo Ku, Kobe, Hyogo 6500017, Japan KobeUniv Kobe Hyogo Japan 6500017 m, Chuo Ku, Kobe, Hyogo 6500017, Japan
Titolo Testata:
FEBS LETTERS
fascicolo: 2-3, volume: 445, anno: 1999,
pagine: 371 - 374
SICI:
0014-5793(19990226)445:2-3<371:COTBCR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; GTP-BINDING PROTEIN; ADP-RIBOSYLATION FACTOR; TYROSINE KINASE; PHOSPHATIDYLCHOLINE HYDROLYSIS; MEDIATED ACTIVATION; PHOSPHORYLATION; STIMULATION; ACID; LYMPHOCYTES;
Keywords:
B cell receptor; phospholipase D; Syk; Btk; phospholipase C-gamma; Src family;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamura, H Kobe Univ, Sch Med, Dept Biochem, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 Kobe, Hyogo 6500017, Japan
Citazione:
T. Hitomi et al., "Cross-linking of the B cell receptor induces activation of phospholipase Dthrough Syk, Btk and phospholipase C-gamma 2", FEBS LETTER, 445(2-3), 1999, pp. 371-374

Abstract

Phospholipase D (PLD) has been proposed to play a key role in the signal transduction of cellular responses to various extracellular signals. Herein me provide biochemical and genetic evidence that cross-linking of the B cell receptor (BCR) induces rapid activation of PLD through a Syk-, Btk- and phospholipase C (PLC)-gamma 2-dependent pathway in DT40 cells. Activation ofPLD upon BCR engagement is completely blocked in Syk- or Btk-deficient cells, but unaffected in Lyn-deficient cells. Furthermore, in PLC- gamma 2-deficient cells, BCR engagement failed to activate PLD. These results demonstrate that Syk, Btk and PLC-gamma 2 are essential for BCR-induced PLD activation. (C) 1999 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:37:54