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Titolo:
Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains
Autore:
Wixler, V; Laplantine, E; Geerts, D; Sonnenberg, A; Petersohn, D; Eckes, B; Paulsson, M; Aumailley, M;
Indirizzi:
Univ Cologne, Fac Med, Inst Biochem 2, D-50931 Cologne, Germany Univ Cologne Cologne Germany D-50931 Biochem 2, D-50931 Cologne, Germany Univ Cologne, Fac Med, Dept Dermatol, D-50931 Cologne, Germany Univ Cologne Cologne Germany D-50931 Dermatol, D-50931 Cologne, Germany Netherlands Canc Inst, Div Cell Biol, Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands iol, Amsterdam, Netherlands
Titolo Testata:
FEBS LETTERS
fascicolo: 2-3, volume: 445, anno: 1999,
pagine: 351 - 355
SICI:
0014-5793(19990226)445:2-3<351:IONIPF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
OUT SIGNAL-TRANSDUCTION; FOCAL ADHESIONS; CELL-ADHESION; SUBUNIT; MSS4; DIFFERENTIATION; SUBFAMILY; DISTINCT; PROTEIN; BIN1;
Keywords:
integrin cytoplasmic domain; alpha 3A beta I integrin receptor; protein-protein interaction; two hybrid system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Wixler, V Univogne,gne, Fac Med, Inst Biochem 2, Joseph Stelzmann Str 52, D-50931 Col Univ Cologne Joseph Stelzmann Str 52 Cologne Germany D-50931 ol
Citazione:
V. Wixler et al., "Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains", FEBS LETTER, 445(2-3), 1999, pp. 351-355

Abstract

The alpha 3A beta 1 integrin is a laminin receptor with a broad specificity for different laminin isoforms. Furthermore, it regulates the function ofother integrins, like alpha 2 beta 1, alpha 5 beta 1 and alpha 6A beta 1. In a yeast two hybrid screen of a human placenta cDNA library, we identified cDNAs coding for four different proteins that strongly interact with the conserved region of the cytoplasmic domain of the alpha 3A integrin subunit. In addition to the cDNA for nucleotide exchange factor Mss4 and the putative tumour suppressor protein BIN1, two novel cDNAs mere identified. Association analysis with different integrin subunits revealed them as cDNAs thatencode binding proteins which react with a broad spectrum of a subunits. The conserved membrane proximal region of the alpha 3A chain was identified as the binding site for all four proteins. They, therefore, may be involvedin the regulation of general functions of integrins. (C) 1999 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:25:36