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Titolo:
Echo planar perfusion imaging with high spatial and temporal resolution: methodology and clinical aspects
Autore:
Bitzer, M; Klose, U; Nagele, T; Friese, S; Kuntz, R; Fetter, M; Opitz, H; Voigt, K;
Indirizzi:
Univ Tubingen, Dept Neuroradiol, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 radiol, D-72076 Tubingen, Germany Univ Tubingen, Dept Neurol, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 Neurol, D-72076 Tubingen, Germany Univ Tubingen, Dept Neurosurg, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 rosurg, D-72076 Tubingen, Germany
Titolo Testata:
EUROPEAN RADIOLOGY
fascicolo: 2, volume: 9, anno: 1999,
pagine: 221 - 229
SICI:
0938-7994(1999)9:2<221:EPPIWH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-VOLUME; MAGNETIC-RESONANCE; NONINVASIVE QUANTIFICATION; CEREBROVASCULAR-DISEASE; CONTRAST; SUSCEPTIBILITY; FLOW; STROKE; TUMOR; BRAIN;
Keywords:
perfusion-weighted MRI; cerebral perfusion; parameter images; cerebrovascular disease; brain tumours;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Bitzer, M Univanybingen, Dept Neuroradiol, Hoppe Seyler Str 3, D-72076 Tubingen, Germ Univ Tubingen Hoppe Seyler Str 3 Tubingen Germany D-72076 Germ
Citazione:
M. Bitzer et al., "Echo planar perfusion imaging with high spatial and temporal resolution: methodology and clinical aspects", EUR RADIOL, 9(2), 1999, pp. 221-229

Abstract

The purpose of the present study was to analyse specific advantages of calculated parameter images and their limitations using an optimized echoplanar imaging (EPI) technique with high spatial and temporal resolution. Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) was performed in 12 patients with cerebrovascular disease and in 13 patients with braintumours. For MR imaging of cerebral perfusion an EPI sequence was developed which provides a temporal resolution of 0.68 s for three slices with a 128 x 128 image matrix. To evaluate DSC-MRI, the following parameter images were calculated pixelwise: (1) Maximum signal reduction (MSR); (2) maximum signal difference (Delta SR); (3) time-to-peak (T-p); and (4) integral of signal-intensity- time curve until T-p (S-Int). The MSR maps were superior inthe detection of acute infarctions and Delta SR maps in the detection of acute infarctions and Delta SR maps in the delineation of vasogenic brain oedema. The time-to-peak (T-p) maps seemed to be highly sensitive in the detection of poststenotic malperfused brain areas (sensitivity 90 %). Hyperperfused areas of brain tumours were detectable down to a diameter of 1 cm withhigh sensitivity (>90 %). Distinct clinical and neuroradiological conditions revealed different suitabilities for the parameter images. The time-to-peak (T-p) maps may be an important advantage in the detection of poststenotic "areas at risk", due to an improved temporal resolution using a EPI technique. With regard to spatial resolution, a matrix size of 128 x 128 is sufficient for all clinical conditions. According to our results, a further increase in matrix size would not improve the spatial resolution of DSC-MRI, since the degree of the vascularization of lesions and the susceptibility effect itself seem to be the limiting factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:14:28