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Titolo:
Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans
Autore:
Fujita, M; Woods, SW; Verhoeff, NPLG; Abi-Dargham, A; Baldwin, RM; Zoghbi, SS; Soares, JC; Jatlow, PA; Krystal, JH; Rajeevan, N; Charney, DS; Seibyl, JP; Innis, RB;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 Med, Dept Psychiat, W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Diagnost Radiol, W Haven, CT 06516 USA Yale UnivW Haven CT USA 06516 ept Diagnost Radiol, W Haven, CT 06516 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 368, anno: 1999,
pagine: 161 - 172
SICI:
0014-2999(19990305)368:2-3<161:COBRDC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBUNIT MESSENGER-RNA; LONG-TERM USE; I-123 IOMAZENIL; CHRONIC LORAZEPAM; DOWN-REGULATION; HYPNOTIC DRUGS; RAT-BRAIN; ALPRAZOLAM; TOLERANCE; DIAZEPAM;
Keywords:
benzodiazepine; GABA(A)/benzodiazepine receptor; (human); down regulation; SPECT (single photon emission computed tomography);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Fujita, M Yale Univ, Sch Med, Dept Psychiat, VA Connecticut 116A2,950 Campbell Ave, W Yale Univ VA Connecticut 116A2,950 Campbell Ave W Haven CT USA 06516
Citazione:
M. Fujita et al., "Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans", EUR J PHARM, 368(2-3), 1999, pp. 161-172

Abstract

Changes of central type GABA(A)/benzodiazepine receptors during 24-day per-oral administration of alprazolam (2 mg/day) were measured with single photon emission computed tomography (SPECT) in nine healthy human subjects. Receptor densities were measured on days -4 (baseline), 3, 10, 17 and 24. Comparison of baseline and day 3 SPECT images was used to assess receptor occupancy; comparisons of the four scans on medication were used to assess alterations in receptor levels. Clinical effects were evaluated by subjective ratings of mood and the Hopkins verbal learning test. Alprazolam induced sedation associated with a 16% receptor occupancy. Unoccupied receptor levels decreased 10% from day 3 to day 10 but then normalized to baseline values by day 17. Clinical effects showed corresponding changes 1-2 weeks after thechanges in the receptor. Thus, the decrease of benzodiazepine receptor densities may be one of the major mechanisms for tolerance development in humans. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:14:07