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Titolo:
Evaluation of dysthymic disorder with technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomography
Autore:
Sarikaya, A; Karasin, E; Cermik, TF; Abay, E; Berkarda, S;
Indirizzi:
Trakya Univ, Fac Med, Dept Nucl Med, TR-22030 Edirne, Turkey Trakya Univ Edirne Turkey TR-22030 ept Nucl Med, TR-22030 Edirne, Turkey Trakya Univ, Fac Med, Dept Psychiat, TR-22030 Edirne, Turkey Trakya Univ Edirne Turkey TR-22030 ept Psychiat, TR-22030 Edirne, Turkey
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 3, volume: 26, anno: 1999,
pagine: 260 - 264
SICI:
0340-6997(199903)26:3<260:EODDWT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; MOOD DISORDERS; FRONTAL-LOBE; DEPRESSION; GLUCOSE; HYPOMETABOLISM; CONSUMPTION; DISEASE;
Keywords:
dysthymic disorder; brain single-photon emission tomography; technetium-99m hexamethylpropylene; amine oxime;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Sarikaya, A Trakya Univ, Fac Med, Dept Nucl Med, TR-22030 Edirne, Turkey Trakya Univ Edirne Turkey TR-22030 , TR-22030 Edirne, Turkey
Citazione:
A. Sarikaya et al., "Evaluation of dysthymic disorder with technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomography", EUR J NUCL, 26(3), 1999, pp. 260-264

Abstract

Dysthymic disorder is a chronic disorder characterised by the presence of a depressed mood and is classified as a distinct category in DSM-IV, separately from major depression. Although brain imaging studies have been performed in major depressive disease, there have to date been no reports of suchstudies in dysthymic disorder. In this study 36 patients with dysthymic disorder were compared with 16 normal subjects using technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomography. A relative blood now ratio was calculated for each region of interest using the average tissue activity in the region divided by activity in the cerebellum. There were significant differences in the bilateral inferior frontal, bilateralparietal, right superior frontal and left posterior temporal regions in the patients with dysthymic disorder compared with the healthy controls. These findings support the hypothesis that the biological bases for dysthymic disorder and major depression are similar. Recognition of these regional abnormalities may have clinical utility in both the diagnosis and the treatment of dysthymic disorder. Further studies are needed to confirm our results and to assess the influence of treatment in patients with dysthymic disorder.

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Documento generato il 05/04/20 alle ore 07:17:01