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Titolo:
Effects of the CYP2D6*10 allele on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia
Autore:
Mihara, K; Suzuki, A; Kondo, T; Yasui, N; Furukori, H; Nagashima, U; Otani, K; Kaneko, S; Inoue, Y;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Yamagata Univ, Sch Med, Dept Neuropsychiat, Yamagata 99023, Japan YamagataUniv Yamagata Japan 99023 Neuropsychiat, Yamagata 99023, Japan Yoshitomi Pharmaceut Ind Ltd, Pharmaceut Technol Ctr, Fukuoka, Japan Yoshitomi Pharmaceut Ind Ltd Fukuoka Japan Technol Ctr, Fukuoka, Japan
Titolo Testata:
CLINICAL PHARMACOLOGY & THERAPEUTICS
fascicolo: 3, volume: 65, anno: 1999,
pagine: 291 - 294
SICI:
0009-9236(199903)65:3<291:EOTCAO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEBRISOQUINE HYDROXYLATION PHENOTYPE; POLYMORPHIC DRUG OXIDATION; POOR METABOLIZERS; GENETIC-ANALYSIS; DISPOSITION; CAPACITY; LOCUS; SERUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Mihara, K Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 mori 0368562, Japan
Citazione:
K. Mihara et al., "Effects of the CYP2D6*10 allele on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia", CLIN PHARM, 65(3), 1999, pp. 291-294

Abstract

Background: The CYP2D6*10 (*10) allele that causes decreased CYP2D6 activity is present in Asians with a high frequency of about 50%. In this study we studied the effects of the *10 allele on the steady-state plasma concentrations (C-ss) of haloperidol and reduced haloperidol. Methods: The subjects were 67 Japanese inpatients with schizophrenia who had only the wild-type or *10 alleles, Thirty-four patients were homozygous for the wild-type allele, and 26 were heterozygous and 7 were homozygous for the *10 allele, All patients had been receiving 12 mg/day haloperidol forat least 2 weeks, Plasma concentrations of haloperidol and reduced haloperidol were measured by HPLC. Results: The mean +/- SD values of haloperidol C-ss in the patients with 0, 1, and 2 *10 alleles were 22.8 +/- 11.0, 30.1 +/- 10.6, and 31.2 +/- 21.2nmol/L, respectively, and those values for reduced haloperidol were 6.1 +/- 2.9, 9.5 +/- 3.7, and 9.9 +/- 6.2 nmol/L, respectively. The mean haloperidol C-ss was significantly (P <.05) higher in the patients with 1 *10 allele than in those with no *10 alleles, The mean C-ss of reduced haloperidol was significantly (P <.05) higher in the patients with 1 and 2 *10 alleles than in those with no *10 alleles,Conclusion: This study suggests that the *10 allele plays an important role in controlling the C-ss of both haloperidol and reduced haloperidol, especially in Asian subjects.

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Documento generato il 20/01/20 alle ore 11:07:52