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Titolo:
A PRELIMINARY-STUDY ON THE EFFICACY OF SERTRALINE AND IMIPRAMINE ON ANGER ATTACKS IN ATYPICAL DEPRESSION AND DYSTHYMIA
Autore:
FAVA M; NIERENBERG AA; QUITKIN FM; ZISOOK S; PEARLSTEIN T; STONE A; ROSENBAUM JF;
Indirizzi:
MASSACHUSETTS GEN HOSP,CLIN PSYCHOPHARMACOL UNIT,DEPRESS RES PROGRAM,15 PARKMAN ST,WAC 815 BOSTON MA 02114 NEW YORK STATE PSYCHIAT INST & HOSP,DEPT PSYCHIAT NEW YORK NY 10032 UNIV CALIF SAN DIEGO,DEPT PSYCHIAT SAN DIEGO CA 92103 BUTLER HOSP,DEPT PSYCHIAT PROVIDENCE RI 02906 UNIV MASSACHUSETTS,MED CTR,DEPT PSYCHIAT WORCESTER MA 01655
Titolo Testata:
Psychopharmacology bulletin
fascicolo: 1, volume: 33, anno: 1997,
pagine: 101 - 103
SICI:
0048-5764(1997)33:1<101:APOTEO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUOXETINE TREATMENT; UNIPOLAR DEPRESSION; OUTPATIENTS;
Keywords:
ANGER ATTACKS; ATYPICAL DEPRESSION; DYSTHYMIA; ANTIDEPRESSANT TREATMENT; NORMAL CONTROLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
M. Fava et al., "A PRELIMINARY-STUDY ON THE EFFICACY OF SERTRALINE AND IMIPRAMINE ON ANGER ATTACKS IN ATYPICAL DEPRESSION AND DYSTHYMIA", Psychopharmacology bulletin, 33(1), 1997, pp. 101-103

Abstract

There is clinical and biological evidence suggesting that patients with anger attacks, sudden spells of anger accompanied by intense autonomic activation, may represent a distinct psychopathological subgroup of patients with depressive disorders. We compared the prevalence of anger attacks in 168 outpatients with atypical depression or primary dysthymia with 38 normal subjects and tested the effect of treatment on anger attacks in a double-blind, placebo-controlled trial of sertralineversus imipramine. Patients were randomly assigned to sertraline (n=56), imipramine (n=52), or placebo (n=60) and were administered the Anger Attacks Questionnaire before and after treatment. Depressed outpatients were significantly more likely to report anger attacks than controls. Anger attacks ceased in 53 percent of the patients receiving sertraline, 57 percent of those receiving imipramine, and 37 percent of those in the placebo group. Our findings support previous studies indicating that anger attacks are more prevalent among depressed outpatientsthan normals. Our results also suggest that sertraline and imipraminemay be more effective than placebo in reducing the number of anger attacks following treatment although the differences were not statistically significant. Larger studies are needed to confirm our findings.

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Documento generato il 22/09/20 alle ore 13:11:15