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Titolo:
Peak compression in semi-preparative supercritical fluid chromatography
Autore:
Owens, PK; Gyllenhaal, O; Karlsson, A; Karlsson, L;
Indirizzi:
Astra Hassle AB, Pharmaceut Res & Dev, Analyt Chem, S-43183 Molndal, Sweden Astra Hassle AB Molndal Sweden S-43183 lyt Chem, S-43183 Molndal, Sweden
Titolo Testata:
CHROMATOGRAPHIA
fascicolo: 5-6, volume: 49, anno: 1999,
pagine: 327 - 332
SICI:
0009-5893(199903)49:5-6<327:PCISSF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIR ADSORPTION CHROMATOGRAPHY; SYSTEM PEAKS; SEPARATION; RESOLUTION; RETENTION; DRUGS;
Keywords:
supercritical fluid chromatography; semi-preparative chromatography; peak compression effect; dihydropyridine drug;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Owens, PK Astra Hassle AB, Pharmaceut Res & Dev, Analyt Chem, S-43183 Molndal, Sweden Astra Hassle AB Molndal Sweden S-43183 S-43183 Molndal, Sweden
Citazione:
P.K. Owens et al., "Peak compression in semi-preparative supercritical fluid chromatography", CHROMATOGR, 49(5-6), 1999, pp. 327-332

Abstract

Peak compression of a dihydropyridine drug, clevidipine, is obtained in both analytical and semi-preparative scale supercritical fluid chromatography, resulting in extremely high apparent efficiencies. The observed effect, when utilising a carbon dioxide/2-propanol mobile phase with a bare silica stationary phase, is achieved when the retention of the clevidipine peak is controlled to coalesce with a system peak, generated as a result of having water in the sample. Apparent efficiencies of 350,000 and 170,000 plates meter(-1) were obtained when 0.25 and 0.5 mg, respectively, are directly injected to a 200 x 4.6 mm ID 5 mu m Hypersil silica packed column. The effect was extended to a semi-preparative system where apparent efficiencies in the region of 2,000,000 plates meter-l were observed when 0.3 mg of a clevidipine sample containing 80 % water was injected to a 250 x 10 mm I.D. columncontaining 5-mu m Hypersil silica particles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 19:48:10