Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dose-dependent effects of DNA-damaging agents on p53-mediated cell cycle arrest
Autore:
Chang, D; Chen, F; Zhang, FF; McKay, BC; Ljungman, M;
Indirizzi:
Univrbor,igan, Dept Radiat Oncol, Div Canc Biol, Ctr Comprehens Canc, Ann A Univ Michigan Ann Arbor MI USA 48109 anc Biol, Ctr Comprehens Canc, Ann A
Titolo Testata:
CELL GROWTH & DIFFERENTIATION
fascicolo: 3, volume: 10, anno: 1999,
pagine: 155 - 162
SICI:
1044-9523(199903)10:3<155:DEODAO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION-COUPLED REPAIR; IRRADIATED HUMAN FIBROBLASTS; WILD-TYPE P53; RETINOBLASTOMA PROTEIN; UV-IRRADIATION; GROWTH ARREST; P53-DEPENDENT MANNER; IONIZING-RADIATION; TUMOR-SUPPRESSOR; RNA-SYNTHESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Ljungman, M UnivCCGC,1500, Dept Radiat Oncol, Div Canc Biol, Ctr Comprehens Canc, 4306 Univ Michigan 4306 CCGC,1500 E Med Ctr Dr Ann Arbor MI USA 48109
Citazione:
D. Chang et al., "Dose-dependent effects of DNA-damaging agents on p53-mediated cell cycle arrest", CELL GROWTH, 10(3), 1999, pp. 155-162

Abstract

We examined the dose-dependent effects of DNA-damaging agents on G(1) arrest in isogenic human cell lines differing in their p53 status. As expected,5 or 20 Gy of ionizing radiation induced a p53-dependent G(1) arrest. In contrast, UV light or actinomycin D induced a modest G(1) arrest that was p53-dependent only at lower doses. At higher doses, cells were arrested in G(1) in a p53-independent manner coinciding with inhibition of RNA synthesis and abolished cyclin E expression. Interestingly, expression of cyclin E was enhanced after exposure to moderate doses of UV light and actinomycin D, and this enhancement was suppressed by wild-type p53, We propose that agents inducing transcription-blocking DNA lesions will at higher doses inhibit the progression of cells into S phase by a p53-independent mechanism involving the attenuation of E2F-mediated transcription of genes, such as cyclin E.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:30:06