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Titolo:
Normal primitive haemopoietic progenitors are more frequent than their leukaemic counterpart in newly diagnosed patients with chronic myeloid leukaemia but rapidly decline with time
Autore:
Frassoni, F; Podesta, M; Piaggio, G; Rosti, V; Pitto, A; Benvenuto, F; Figari, O; Vassallo, F; Carella, AM; Zikos, P; Bergamaschi, G; Fugazza, G; Sessarego, M; Cazzola, M;
Indirizzi:
Osped San Martino Genova, Div Ematol 2, I-16132 Genoa, Italy Osped San Martino Genova Genoa Italy I-16132 tol 2, I-16132 Genoa, Italy Univ-27100, IRCCS, Policlin San Matteo, Dipartimento Med Interna & Oncol, I Univ Pavia Pavia Italy I-27100 tteo, Dipartimento Med Interna & Oncol, I Univ Genoa, DIMI, Genoa, Italy Univ Genoa Genoa ItalyUniv Genoa, DIMI, Genoa, Italy
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 3, volume: 104, anno: 1999,
pagine: 538 - 545
SICI:
0007-1048(199903)104:3<538:NPHPAM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; HEMATOPOIETIC-CELLS; PHILADELPHIA-CHROMOSOME; REPOPULATING CELLS; LIMITING DILUTION; PERIPHERAL-BLOOD; CHRONIC PHASE; MARROW-CELLS; BONE-MARROW; TRANSPLANTATION;
Keywords:
chronic myeloid leukaemia; haemopoiesis; long-term culture-initiating cells; stem cells; stem cell transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Frassoni, F Osped San Martino Genova, Div Ematol 2, I-16132 Genoa, Italy Osped San Martino Genova Genoa Italy I-16132 32 Genoa, Italy
Citazione:
F. Frassoni et al., "Normal primitive haemopoietic progenitors are more frequent than their leukaemic counterpart in newly diagnosed patients with chronic myeloid leukaemia but rapidly decline with time", BR J HAEM, 104(3), 1999, pp. 538-545

Abstract

We carried out studies to quantify Ph-negative progenitors both in steady state and during regeneration after chemotherapy and G-CSF in 23 newly diagnosed chronic myeloid leukaemia (CML) patients (group A) and in 14 individuals more than a year from diagnosis (nine in chronic and five in accelerated phase, group B), In steady state bone marrow Ph-negative long-term culture initialing cells (LTC-IC) and Ph-negative colony-forming-cells (CFC) weredetected in 18/23 and 14/23 patients of group A versus 3/14 and 3/14 patients of group B (P< 0.001 and P< 0.02, respectively), The absolute number ofmobilized Ph-negative progenitors was markedly higher in group A versus group B (P <0.02 for LTC-TC, P< 0.003 for CFC), 12/16 newly diagnosed patients mobilized Ph-negative LTC-IC only and the yield was in the range of normal allogeneic donors, Overall the frequency of Ph-negative LTC-IC in the bone marrow predicted the yield of Ph-negative LTC-IC mobilized into peripheral blood (P<0.001). The bone marrow frequency of Ph-positive LTC-IC was considerably lower than the normal counterpart, Taken together these findings suggest that normal progenitors are relatively well preserved in newly diagnosed CML patients, but tend to rapidly decline with time. This observation helps in the understanding of the pathogenesis of CML and has potential implications for autografting, The optimal time for a successful collection ofPh-negative circulating progenitors would appear to be soon after diagnosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 10:52:50