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Titolo:
Malignant tumours and psoriasis: a follow-up study
Autore:
Frentz, G; Olsen, JH;
Indirizzi:
Danish Canc Soc, Inst Canc Epidemiol, DK-2100 Copenhagen 0, Denmark DanishCanc Soc Copenhagen Denmark 0 miol, DK-2100 Copenhagen 0, Denmark Copenhagen Municipal Hosp, Inst Prevent Med, DK-1399 Copenhagen, Denmark Copenhagen Municipal Hosp Copenhagen Denmark DK-1399 Copenhagen, Denmark
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 2, volume: 140, anno: 1999,
pagine: 237 - 242
SICI:
0007-0963(199902)140:2<237:MTAPAF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN-CANCER; PUVA; PSORALEN; DEATH; RISK;
Keywords:
lifetime risk; malignant tumours; non-melanoma skin cancer; psoriasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Olsen, JH Danishgennc Soc, Inst Canc Epidemiol, Strandboulevarden 49, DK-2100 Copenha Danish Canc Soc Strandboulevarden 49 Copenhagen Denmark 0 penha
Citazione:
G. Frentz e J.H. Olsen, "Malignant tumours and psoriasis: a follow-up study", BR J DERM, 140(2), 1999, pp. 237-242

Abstract

This nationwide follow-up study concerns the pattern of malignant tumours in a cohort of patients with psoriasis, at an average of 9.3 years after discharge from hospital. The study confirms that the significantly increased risk of cancer in these patients, amounting to 1.4 times that in the general population, is mainly due to cancer of the skin and lung in both sexes and cancer of the pharynx and larynx in men. Non-melanoma skin cancer is the most common malignancy, occurring in 196 of 795 patients with cancer: standardized incidence ratio (SIR, the ratio of observed to expected cancers) 2.4 for men and 2.6 for women. This means an overall lifetime risk (up to theage of 75 years) of 14.1%. In particular, squamous cell carcinoma (SCC) byitself (n = 45, SIR 3.9 for men and 4.7 for women), cancer in multiple sites (SIR 5.9 for basal cell carcinoma (BCC) and 11.7 for (SCC) and SCC on the lower extremities (SIR 18.0) are frequent. Women run the highest risk of BCC in the age range 20-40 years, while men in the age range 30-60 years run a particularly high risk of SCC. When monitoring patients extensively treated for psoriasis, this aberrant pattern of cancer should be taken into account.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:44:32