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Titolo:
MODULATION OF LUMINOL-DEPENDENT CHEMILUMINESCENCE OF MURINE MACROPHAGES BY FLAVONE AND ITS SYNTHETIC DERIVATIVES
Autore:
KROL W; CZUBA ZP; THREADGILL MD; CUNNINGHAM BDM; SHANI J;
Indirizzi:
L WARYNSKI SILESIAN MED ACAD,DEPT MICROBIOL & IMMUNOL PL-41808 ZABRZEPOLAND UNIV BATH,SCH PHARM & PHARMACOL BATH BA2 7AY AVON ENGLAND ONCOGENE SCI INC UNIONDALE NY 00000 HEBREW UNIV JERUSALEM,SCH PHARM,DEPT PHARMACOL IL-91120 JERUSALEM ISRAEL
Titolo Testata:
Arzneimittel-Forschung
fascicolo: 7, volume: 45, anno: 1995,
pagine: 815 - 818
SICI:
0004-4172(1995)45:7<815:MOLCOM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ACETIC-ACID NSC-347512; KILLER CELL-ACTIVITY; SUPEROXIDE PRODUCTION; BIOFLAVONOID QUERCETIN; FLAVONE-8-ACETIC ACID; ANTITUMOR-ACTIVITY; ETHANOLIC EXTRACT; NATURAL-PRODUCTS; C3H/HEJ MICE;
Keywords:
3'-AMINO-4'-HYDROXYFLAVONE; CAS 87626-55-9; FLAVONE-8-ACETIC ACID; FLAVONES; MACROPHAGES, MODULATION OF CHEMILUMINESCENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
W. Krol et al., "MODULATION OF LUMINOL-DEPENDENT CHEMILUMINESCENCE OF MURINE MACROPHAGES BY FLAVONE AND ITS SYNTHETIC DERIVATIVES", Arzneimittel-Forschung, 45(7), 1995, pp. 815-818

Abstract

The effect of flavone (CAS 525-82-6, 2-phenylbenzopyran-4-one, 1), flavone-8-acetic acid (CAS 87626-55-9, FAA, 2) and 10 substituted flavones on the luminol-dependent chemiluminescence of murine macrophages was studied in vitro. The synthetic derivatives were variously substituted with halo, nitro, amino, hydroxy and methoxy substituents in the 3'and 4' positions. Chemiluminescence was used in this study as an indicator for the production of reactive oxygen species by macrophages, stimulated in vitro by phorbol myristate acetate (PMA). All flavones except FAA (2) showed more than 20% inhibition at 10 mu mol/l or 100 mu mol/l. 3'-Amino-4'-hydroxyflavone (8) was the most potent inhibitor. The IC(50)s for inhibition of chemiluminescence were 4.2 +/- 1.1 mu mol/l, 5.0 +/- 1.0 mu mol/l and 3.3 +/- 1.4 mu mol/l for resident, elicited and LPS-Poly I:C-primed macrophages, respectively. Small but statistically significant enhancements of chemiluminescence were caused by low concentrations of flavone (1), FAA (2) and 4'-methoxyflavone (6). These results suggest that modulation of the chemiluminescent capacity of macrophages depends on the nature of the substituents and the concentration of the flavones.

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Documento generato il 28/11/20 alle ore 21:35:23