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Titolo:
Lactation-induced reduction in rats' acoustic startle is associated with changes in noradrenergic neurotransmission
Autore:
Toufexis, DJ; Rochford, J; Walker, CD;
Indirizzi:
McGillnadav, Res Ctr, Dept Psychiat, Douglas Hosp, Montreal, PQ H4H 1R3, Ca McGill Univ Montreal PQ Canada H4H 1R3 las Hosp, Montreal, PQ H4H 1R3, Ca McGilldaniv, Res Ctr, Dept Neurol, Douglas Hosp, Montreal, PQ H4H 1R3, Cana McGill Univ Montreal PQ Canada H4H 1R3 s Hosp, Montreal, PQ H4H 1R3, Cana
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 1, volume: 113, anno: 1999,
pagine: 176 - 184
SICI:
0735-7044(199902)113:1<176:LRIRAS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; PONTINE RETICULAR-FORMATION; MATERNAL-BEHAVIOR; BRAIN-STEM; FEMALE RAT; AMYGDALA; STRESS; NEURONS; NUCLEUS; REFLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Walker, CD McGilleal,v, Res Ctr, Dept Psychiat, Douglas Hosp, 6875 LasalleBlvd, Montr McGill Univ 6875 Lasalle Blvd Montreal PQ Canada H4H 1R3 Montr
Citazione:
D.J. Toufexis et al., "Lactation-induced reduction in rats' acoustic startle is associated with changes in noradrenergic neurotransmission", BEHAV NEURO, 113(1), 1999, pp. 176-184

Abstract

The acoustic startle response (ASR) with or without fear conditioning was compared between cycling (CYC) and lactating (LACT) female rats. ASR sensitivity to changes in endogenous noradrenergic (NA) release was examined using the alpha-2 NA receptor drugs yohimbine and clonidine. Groups of CYC and LACT females were also tested in the open field. ASR was reduced in all LACT compared with that in CYC females. Both groups exhibited a robust response to fear conditioning and unpotentiated ASR subsequent to conditioning wasincreased in LACT females. The lowest dose of yohimbine significantly increased ASR in LACT females, but not in CYC females. Clonidine reduced ASR inboth groups of females, with a greater potency in CYC females. In the openfield, LACT females displayed a shorter latency to emerge, less freezing behavior, and more entries into the field than did CYC females. The authors concluded that (a) LACT females are less anxious in a novel environment andthat decreased anxiety can be efficiently counteracted by fear conditioning, and (b) changes in NA neurotransmission contribute to lactation-induced modifications in ASR.

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Documento generato il 04/07/20 alle ore 05:23:43