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Titolo:
The dopaminergic modulation of fear: Quinpirole impairs the recall of emotional memories in rats
Autore:
Nader, K; LeDoux, J;
Indirizzi:
NYU, Ctr Neural Sci, New York, NY 10003 USA NYU New York NY USA 10003NYU, Ctr Neural Sci, New York, NY 10003 USA
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 1, volume: 113, anno: 1999,
pagine: 152 - 165
SICI:
0735-7044(199902)113:1<152:TDMOFQ>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; SELF-ADMINISTRATION BEHAVIOR; CONDITIONED REINFORCEMENT; POTENTIATED STARTLE; FREEZING BEHAVIOR; LATENT INHIBITION; AMYGDALA; STRESS; AMPHETAMINE; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Nader, K NYU, Ctr Neural Sci, 4 Washington Pl,Room 1105, New York, NY 10003 USA NYU 4 Washington Pl,Room 1105 New York NY USA 10003 NY 10003 USA
Citazione:
K. Nader e J. LeDoux, "The dopaminergic modulation of fear: Quinpirole impairs the recall of emotional memories in rats", BEHAV NEURO, 113(1), 1999, pp. 152-165

Abstract

Past studies examining the contributions of dopamine to fear have producedinconsistent results. The present experiments reevaluated this issue. It was found that systemic pretreatment with the D2 agonist quinpirole before pairing 2 conditioned stimuli (CSs; CS2-CS1) dose dependently blocked the acquisition of second-order fear conditioning. Quinpirole's actions were not due to nonspecific impairments in the ability to perceive the CSs, or form and store an association, because the identical drug pretreatment before pairing the same 2 CSs had no effect on the acquisition of sensory preconditioning. In a separate study, rats were given fear conditioning while untreated and then received extinction sessions while under the influence of quinpirole or its vehicle. Quinpirole pretreatment blocked extinction. Findings suggest that quinpirole decreased fear by blocking the retrieval of a learned association between a CS and unconditioned stimulus (US), rather than bydevaluing the US, which would have resulted from summation of quinpirole'sappetitive properties with the aversive properties of fear.

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Documento generato il 07/07/20 alle ore 12:28:41