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Titolo:
Effects of joint lavage and steroid injection in patients with osteoarthritis of the knee - Results of a multicenter, randomized, controlled trial
Autore:
Ravaud, P; Moulinier, L; Giraudeau, B; Ayral, X; Guerin, C; Noel, E; Thomas, P; Fautrel, B; Mazieres, B; Dougados, M;
Indirizzi:
Hop Cochin, Serv Rheumatol B, F-75014 Paris, France Hop Cochin Paris France F-75014 Serv Rheumatol B, F-75014 Paris, France Univ Paris 05, Paris, France Univ Paris 05 Paris FranceUniv Paris 05, Paris, France Hop Rangueil, Toulouse, France Hop Rangueil Toulouse FranceHop Rangueil, Toulouse, France Ctr Rech Clin, Tours, France Ctr Rech Clin Tours FranceCtr Rech Clin, Tours, France Hop Edouard Herriot, Paris, France Hop Edouard Herriot Paris FranceHop Edouard Herriot, Paris, France Ctr Hosp Reg Metz, Metz, France Ctr Hosp Reg Metz Metz FranceCtr Hosp Reg Metz, Metz, France Hop La Pitie Salpetriere, Paris, France Hop La Pitie Salpetriere Paris France Pitie Salpetriere, Paris, France
Titolo Testata:
ARTHRITIS AND RHEUMATISM
fascicolo: 3, volume: 42, anno: 1999,
pagine: 475 - 482
SICI:
0004-3591(199903)42:3<475:EOJLAS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRA-ARTICULAR STEROIDS; OSTEO-ARTHRITIS; LONGITUDINAL DATA; MEDICAL-MANAGEMENT; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ravaud, P Hopancehin, Serv Rheumatol B, 27 Rue Faubourg St Jacques, F-75014 Paris, Fr Hop Cochin 27 Rue Faubourg St Jacques Paris France F-75014 , Fr
Citazione:
P. Ravaud et al., "Effects of joint lavage and steroid injection in patients with osteoarthritis of the knee - Results of a multicenter, randomized, controlled trial", ARTH RHEUM, 42(3), 1999, pp. 475-482

Abstract

Objective. To evaluate the efficacy of joint lavage and intraarticular steroid injection, alone and in combination, in the treatment of patients withsymptomatic knee osteoarthritis (OA). Methods. Ninety-eight patients with painful tibiofemoral OA were enrolled in a prospective, randomized, controlled, 2 x 2 factorial-design trial of 6months' duration. The 4 treatment groups consisted of 1) intraarticular placebo (1.5 ml of 0.9% normal saline), 2) intraarticular corticosteroids (3.75 mg of cortivazol in 1.5 mi), 3) joint lavage and intraarticular placebo,and 4) joint lavage and intraarticular corticosteroid, Outcome measures evaluated at baseline, week 1, week 4, week 12, and week 24 included severityof pain (100-mm visual analog scale [VAS]), global status (100-mm VAS), and Lequesne's functional index. Results. No interaction between steroid injection and joint lavage was demonstrated. Patients who had undergone joint lavage had significantly improved pain VAS scores at week 24 (P = 0.020). In contrast, corticosteroid injection had no long-term effect (P = 0.313); corticosteroid injection was associated with a decrease in pain only at week 1 (P = 0.003) and week 4 (P = 0.020). After week 4, Lequesne's functional index was not significantly improved regardless of the assigned treatment. Conclusion, Compared with placebo, both treatments significantly relieved pain but did not improve functional impairment. The effects of the 2 treatments were additive. Cortivazol provided short-term relief of pain (up to week 4). The effects of joint lavage persisted up to week 24.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:17:35