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Titolo:
Development of mechanoreceptor numbers in embryonic chick-quail chimeras
Autore:
Grim, M; Zelena, J; Halata, Z; Valasek, P; Szeder, V; Jerabkova, G;
Indirizzi:
Charles Univ, Fac Med 1, Inst Anat, CZ-12800 Prague 2, Czech Republic Charles Univ Prague Czech Republic 2 , CZ-12800 Prague 2, Czech Republic Acad Sci Czech Republ, Inst Physiol, Prague, Czech Republic Acad Sci CzechRepubl Prague Czech Republic iol, Prague, Czech Republic Univ Hamburg, Inst Anat, Hamburg, Germany Univ Hamburg Hamburg GermanyUniv Hamburg, Inst Anat, Hamburg, Germany
Titolo Testata:
ANATOMY AND EMBRYOLOGY
fascicolo: 4, volume: 199, anno: 1999,
pagine: 349 - 355
SICI:
0340-2061(199904)199:4<349:DOMNIE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; MUSCLE-SPINDLES; PACINIAN CORPUSCLES; NEONATAL RATS; CELL-DEATH; INNERVATION; IMMUNOREACTIVITY; DIFFERENTIATION; NEUROTROPHIN-3; DENERVATION;
Keywords:
herbst corpuscles; muscle spindles; white leghorn fowl; Japanese quail; quantitative study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Grim, M Charles Univ, Fac Med 1, Inst Anat, U Nemocnice 3, CZ-12800 Prague2, Czech Charles Univ U Nemocnice 3 Prague Czech Republic 2 rague 2, Czech
Citazione:
M. Grim et al., "Development of mechanoreceptor numbers in embryonic chick-quail chimeras", ANAT EMBRYO, 199(4), 1999, pp. 349-355

Abstract

Our experiments addressed the problem of the regulation of the number of mechanoreceptors by sensory axons and/or their peripheral target tissues. According to a previous study (Zelena et al. 1997) white leghorn chickens have more muscle spindles in the plantaris muscle (45.4+/-7.8; mean +/-SD) than the Japanese quail (35.3+/-4.8) and significantly more Herbst corpuscles in the crural region (380.0+/-85.0) than the quail (124.9+/-32.8). Embryonic chick-quail chimeras were therefore used as a model with distinct recombinations of the nerve supply and peripheral tissue for studying the developmental control of these mechanoreceptors. The chick host leg bud was replaced with a quail leg bud of equal age and vice versa on embryonic day 3, prior to the onset of innervation of the periphery. Shortly before hatching thechimeras were sacrificed and muscle spindles and Herbst corpuscles counted. Recombinations of chicken nerves with quail limb buds have shown that thericher nerve supply by chick Ta axons induced a significant increase in the number of muscle spindles in the plantaris muscles (55.5+/-13.4) of the grafted quail limb. Tn some instances, a similar increase in spindle numberswas also found in control legs grafted onto hosts of the same species. In the reverse type of chimera where chick embryo legs were grafted onto quailhosts, spindles developed in lower numbers (27.3+/-3.2). In that case the lower number of Ia axons in quail nerves induced a lower number of spindlesin the chicken muscle. The numbers of Herbst corpuscles were, however, lowin both types of chimera. Quail legs grafted onto host chick embryos contained 126.8+26.4 corpuscles, presumably due to a restrictive influence of the smaller crural area in the quail. Chick legs grafted onto quail hosts hadonly 99.6+34.1 crural corpuscles; the target area in chick embryo legs failed to attract more quail axons and/or to induce axonal sprouting. The developmental regulation of the number of the two types of mechanoreceptors examined in our study thus differ. While sensory axons appear to play the dominant role in the development of muscle spindles, their role seems to be restricted by hitherto unknown peripheral factors during the development of Herbst corpuscles.

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Documento generato il 26/09/20 alle ore 13:35:47