Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section
Autore:
Dansereau, J; Joshi, AK; Helewa, ME; Doran, TA; Lange, IR; Luther, ER; Farine, D; Schulz, ML; Horbay, GLA; Griffin, P; Wassenaar, W;
Indirizzi:
Univ British Columbia, British Columbia Womens Hosp, Vancouver, BC V5Z 1M9, Univ British Columbia Vancouver BC Canada V5Z 1M9 Vancouver, BC V5Z 1M9, McGill Univ, St Marys Hosp, Montreal, PQ H3A 2T5, Canada McGill Univ Montreal PQ Canada H3A 2T5 Hosp, Montreal, PQ H3A 2T5, Canada Univ Manitoba, St Boniface Hosp, Winnipeg, MB R3T 2N2, Canada Univ Manitoba Winnipeg MB Canada R3T 2N2 sp, Winnipeg, MB R3T 2N2, Canada Univ Toronto, Toronto Hosp, Toronto, ON, Canada Univ Toronto Toronto ON Canada oronto, Toronto Hosp, Toronto, ON, Canada Univ Calgary, Foothills Prov Gen Hosp, Calgary, AB T2N 1N4, Canada Univ Calgary Calgary AB Canada T2N 1N4 Hosp, Calgary, AB T2N 1N4, Canada Dalhousie Univ, Grace Matern Hosp, Halifax, NS B3H 3J5, Canada Dalhousie Univ Halifax NS Canada B3H 3J5 osp, Halifax, NS B3H 3J5, Canada Dalhousie Univ, Victoria Gen Hosp, Halifax, NS B3H 3J5, Canada Dalhousie Univ Halifax NS Canada B3H 3J5 osp, Halifax, NS B3H 3J5, Canada Univ Toronto, St Michaels Hosp, Toronto, ON M5B 1W8, Canada Univ Toronto Toronto ON Canada M5B 1W8 Hosp, Toronto, ON M5B 1W8, Canada Ferring Inc, Toronto, ON, Canada Ferring Inc Toronto ON CanadaFerring Inc, Toronto, ON, Canada
Titolo Testata:
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
fascicolo: 3, volume: 180, anno: 1999,
parte:, 1
pagine: 670 - 676
SICI:
0002-9378(199903)180:3<670:DCOCVO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
3RD STAGE; MANAGEMENT; LABOR; ANALOG;
Keywords:
uterine contraction; obstetric hemorrhage; oxytocics; oxytocin; uterotonic activity; cesarean section;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Dansereau, J Victoria Gen Hosp, 35 Helmeken Rd, Victoria, BC V8Z 6R5, Canada Victoria Gen Hosp 35 Helmeken Rd Victoria BC Canada V8Z 6R5 a
Citazione:
J. Dansereau et al., "Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section", AM J OBST G, 180(3), 1999, pp. 670-676

Abstract

OBJECTIVE: The goal of this study was to compare carbetocin, a long-actingoxytocin analog, with oxytocin in the prevention of uterine atony after cesarean section. STUDY DESIGN: We enrolled 694 patients undergoing elective cesarean section in a Canadian multicenter, double-blind, randomized clinical trial. We compared the effect of a single 100 mu g dose of carbetocin with that of a standard 8-hour infusion of oxytocin. The primary outcome was the proportion of patients requiring additional oxytocic intervention for uterine atony. Avariable sample size, sequential design was used. RESULTS: The overall oxytocic intervention rate was 7.4%. The odds of treatment failure requiring oxytocic intervention was 2.03 (95% confidence interval 1.1 to 2.8) times higher in the oxytocin group compared with the carbetocin group, respectively, 32 of 318 (10.1%) versus 15 of 317 (4.7%), P < .05. CONCLUSIONS: Carbetocin, a new drug for the prevention of uterine atony, appears to be more effective than a continuous infusion of oxytocin and has a similar safety profile.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:13:27