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Titolo:
Xanthogranuloma of the sellar region: a clinicopathological entity different from adamantinomatous craniopharyngioma
Autore:
Paulus, W; Honegger, J; Keyvani, K; Fahlbusch, R;
Indirizzi:
WWU Munster, Inst Neuropathol, D-48129 Munster, Germany WWU Munster Munster Germany D-48129 europathol, D-48129 Munster, Germany Univ Erlangen Nurnberg, Dept Neuropathol, D-8520 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-8520 D-8520 Erlangen, Germany Univ Erlangen Nurnberg, Dept Neurosurg, D-8520 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-8520 D-8520 Erlangen, Germany
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 4, volume: 97, anno: 1999,
pagine: 377 - 382
SICI:
0001-6322(199904)97:4<377:XOTSRA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAPILLARY CRANIOPHARYNGIOMA; CHOLESTEROL GRANULOMA; CYST; MR;
Keywords:
adenohypophysis; cholesterol granuloma; craniopharyngioma; sellar lesions; pituitary;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Paulus, W WWU Munster, Inst Neuropathol, Domagkstr 19, D-48129 Munster, Germany WWU Munster Domagkstr 19 Munster Germany D-48129 nster, Germany
Citazione:
W. Paulus et al., "Xanthogranuloma of the sellar region: a clinicopathological entity different from adamantinomatous craniopharyngioma", ACT NEUROP, 97(4), 1999, pp. 377-382

Abstract

Xanthogranulomatous change of craniopharyngioma, consisting of cholesterolclefts, macrophages, chronic inflammatory infiltrates, necrotic debris andhemosiderin deposits, has been traditionally considered a hallmark of the adamantinomatous variant, even in the absence of epithelium. Based on a series of 110 craniopharyngioma patients undergoing primary surgery, we found 37 specimens with a predominating xanthogranulomatous component. Only 3 of these cases (8%) exhibited additional histological features of adamantinomatous craniopharyngioma, while 13 cases (35%) contained non-adamantinomatousepithelium composed of squamous or ciliated cuboidal cells. Subsequent clinical analysis revealed that these 37 xanthogranulomatous lesions differed from 59 classical adamantinomatous craniopharyngiomas with respect to preferential occurrence in adolescents and young adults (mean age 27 years), predominant intrasellar location, smaller tumor size, more severe endocrinological deficits, longer preoperative history, lower frequency of calcification and visual disturbances, better resectability, and a more favorable outcome. On the other hand, xanthogranulomatous and adamantinomatous lesions didnot differ with respect to sex, amount of cystic components, or the intraoperative aspect, considered by the neurosurgeon as being typical for craniopharyngioma in all cases. We suggest that xanthogranuloma (cholesterol granuloma) of the sellar region is clinically and pathologically distinct from the classical adamantinomatous craniopharyngioma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:23:13