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Titolo:
CARDIOPROTECTIVE EFFECTS OF ADENOSINE A(1) AND A(2A) RECEPTOR AGONISTS IN THE ISOLATED RAT-HEART
Autore:
LOZZA G; CONTI A; ONGINI E; MONOPOLI A;
Indirizzi:
SCHERING PLOUGH RES INST,SAN RAFFAELE SCI PK,VIA OLGETTINA 58 I-20132MILAN ITALY
Titolo Testata:
Pharmacological research
fascicolo: 1, volume: 35, anno: 1997,
pagine: 57 - 64
SICI:
1043-6618(1997)35:1<57:CEOAAA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED PROTECTION; SELECTIVE AGONISTS; K+ CHANNELS; ADENOSINE-A1-RECEPTOR; ISCHEMIA; INJURY; RELEASE; DERIVATIVES; ACTIVATION; MECHANISM;
Keywords:
ADENOSINE RECEPTORS; A(1) AGONISTS; A(2A) AGONISTS; ISOLATED RAT HEART; ISCHEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
G. Lozza et al., "CARDIOPROTECTIVE EFFECTS OF ADENOSINE A(1) AND A(2A) RECEPTOR AGONISTS IN THE ISOLATED RAT-HEART", Pharmacological research, 35(1), 1997, pp. 57-64

Abstract

It has been postulated that the adenosine Al receptor subtype, but also A(2A) receptors, are involved in mediating the beneficial properties of adenosine during ischemia and reperfusion. We investigated the effects of the selective A(1) adenosine receptor agonist, 2-chloro-N-6-cyclopentyladenosine (CCPA), the selective A(2A) adenosine receptor agonists, 2-[p-(2-carboxyethyl)phenetylamino] -5'-N-ethylcarboxamidoadenosine (CGS 21680), 2-hexynyl-5'-N-ethyl-carboxamidoadenosine (2HE-NECA), and the non selective agonist, 5'-N-ethyl-carboxamidoadenosine (NECA), on ischemia-reperfusion injury in Langendorff-perfused rat hearts. Global ischemia was induced for 15 min in paced hearts followed by 60 min reperfusion. Control hearts developed left ventricular dysfunction, as indicated by the increase in end diastolic pressure to 40.8+/-5.1vs 5.9+/-1.0 mm Hg baseline, and in coronary perfusion pressure to 57.6+/-8.4 vs 28.8+/-2.2 mm Hg before ischemia. After 15 min of reperfusion, ventricular function (LVDP) recovered by 83%, but creatine kinaselevels were still significantly increased (294+/-55 IUl(-1) vs basal), indicating the occurrence of myocardial injury. All adenosine agonists added to the perfusion medium 15 min prior to ischemia exerted protective effects against myocardial dysfunction and reperfusion injury. Thus, 2HE-NECA (100 nM), CGS 21680 (10 nM), CCPA (3 nM) and NECA (100 nM) significantly (P<0.05) decreased end diastolic pressure by 50-75% as compared with the control group. Similarly, all compounds significantly (P<0.05) reduced coronary perfusion pressure by 30-45% vs control. For all drugs, recovery of LVDP occurred immediately after restoration of coronary flow. At 15-min reperfusion the adenosine agonists decreased myocardial creatine kinase release by 80-95% (P<0.05 vs control). These findings indicate that both A(1) and A(2A) adenosine receptorsare involved in protecting the myocardium against ischemia and reperfusion in isolated rat heart, even if through different mechanisms. (C)1997 The Italian Pharmacological Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:59:17