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Titolo:
Vitamin K intake and sensitivity to warfarin in patients consuming regulardiets
Autore:
Lubetsky, A; Dekel-Stern, E; Chetrit, A; Lubin, F; Halkin, H;
Indirizzi:
Chaimraelba Med Ctr, Dept Med, Anticoagulat Clin, IL-52621 Tel Hashomer, Is Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 -52621 Tel Hashomer, Is Chaim Sheba Med Ctr, Dept Clin Epidemiol, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 21 Tel Hashomer, Israel Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ch Med, IL-69978 Tel Aviv, Israel
Titolo Testata:
THROMBOSIS AND HAEMOSTASIS
fascicolo: 3, volume: 81, anno: 1999,
pagine: 396 - 399
SICI:
0340-6245(199903)81:3<396:VKIAST>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESISTANCE; ANTICOAGULATION; FOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Halkin, H Chaimraelba Med Ctr, Dept Med, Anticoagulat Clin, IL-52621 Tel Hashomer, Is Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 Hashomer, Is
Citazione:
A. Lubetsky et al., "Vitamin K intake and sensitivity to warfarin in patients consuming regulardiets", THROMB HAEM, 81(3), 1999, pp. 396-399

Abstract

The effect of dietary vitamin K intake on warfarin sensitivity is known only from case reports and few small clinical studies. We followed 50 patients commencing warfarin and consuming their regular diets (for 8 weeks) to study this relationship. A one-week recall dietary questionnaire was completed at weeks 2 and 8. Daily intake of nutrients and vitamin K was calculated from standard tables. Warfarin sensitivity index (WIS) was defined as finalINR/final warfarin dose (mg/day/m(2) of body surface area) (week 8). Vitamin K intake was 17-974 (median: 179) mu g/day. Median WSI was 0.82 (0.31-4.47). A WSI value of 1.1 significantly separated excess (greater than or equal to 250 mu g/day) from normal (<250 mu g/day) vitamin K consumers (16/18 vs. 15/32, respectively, p < 0.01), The former had lower day 5 INR (median: 1.9 vs. 3.0, p < 0.001), needed more warfarin to achieve INR greaterthan or equal to 2.0 (32.0 +/- 9.2 mg vs. 25.4 +/- 6.4 mg, p = 0.009) and required a higher maintenance steady state warfarin dose (5.7 +/- 1.7 mg/day vs. 3.5 +/- 1.0 mg/day, p < 0.001). We conclude that in 32% (16/50) of anticoagulated patients under usual dietary conditions sensitivity to warfarin is decreased by vitamin K intake greater than or equal to 250 mu g/day.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 01:02:21