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Titolo:
Hypothalamo-pituitary-adrenal axis and growth hormone axis in patients with rheumatoid arthritis
Autore:
Demir, H; Kelestimur, F; Tunc, M; Kirnap, M; Ozugul, Y;
Indirizzi:
Erciyesayseri,Tip Fak Kayseri, Sch Med, Dept Phys Med & Rehabil, TR-38039 K Erciyes Univ Kayseri Turkey TR-38039 Dept Phys Med & Rehabil, TR-38039 K Erciyes Univ, Sch Med, Dept Endocrinol, TR-38039 Kayseri, Turkey Erciyes Univ Kayseri Turkey TR-38039 ndocrinol, TR-38039 Kayseri, Turkey
Titolo Testata:
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
fascicolo: 1, volume: 28, anno: 1999,
pagine: 41 - 46
SICI:
0300-9742(1999)28:1<41:HAAGHA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; NECROSIS-FACTOR-ALPHA; SECRETION; INTERLEUKIN-6; CYTOKINES; RECEPTORS; RESPONSES; INVITRO; IMMUNE; RAT;
Keywords:
rheumatoid arthritis; hypothalamo-pituitary-adrenal axis; growth hormone axis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Demir, H Erciyesayseri,Tip Fak Kayseri, Sch Med, Dept Phys Med & Rehabil, TR-38039 K Erciyes Univ Kayseri Turkey TR-38039 Med & Rehabil, TR-38039 K
Citazione:
H. Demir et al., "Hypothalamo-pituitary-adrenal axis and growth hormone axis in patients with rheumatoid arthritis", SC J RHEUM, 28(1), 1999, pp. 41-46

Abstract

Rheumatoid arthritis (RA) is a systemic disease and is associated with cytokines (IL-1, IL-6, TNF-alpha) production. There is little information on hypothalamo-pituitary-adrenal (HPA) axis and growth hormone (GH) axis in thepatients with RA. We have, therefore, investigated these systems in twentypatients with confirmed RA. Ten of the patients had active and 10 patientsremitted RA. Serum cortisol, ACTH and GH levels were measured in the basalstate and after insulin induced hypoglycaemia. Cortisol, adrenocorticotropic hormone (ACTH) and GH responses were impaired in 65%, 85% and 30% of thepatients, respectively. The basal and peak hormone levels were similar between the patients with active RA and the patients in remission. These findings indicate that there is an impairment in HPA and GH axis in patients with active and remitted RA. The site of this impairment is probably hypothalamus and/or pituitary gland.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:53:02