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Titolo:
Fibrolamellar carcinoma of the liver: Radiologic-pathologic correlation
Autore:
McLarney, JK; Rucker, PT; Bender, GN; Goodman, ZD; Kashitani, N; Ros, PR;
Indirizzi:
Armed Forces Inst Pathol, Dept Radiol Pathol, Washington, DC 20306 USA Armed Forces Inst Pathol Washington DC USA 20306 Washington, DC 20306 USA ArmedSAorces Inst Pathol, Dept Hepatobillary Pathol, Washington, DC 20306 U Armed Forces Inst Pathol Washington DC USA 20306 , Washington, DC 20306 U Okayama Univ, Dept Radiol, Okayama, Japan Okayama Univ Okayama JapanOkayama Univ, Dept Radiol, Okayama, Japan Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 pt Radiol, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA
Titolo Testata:
RADIOGRAPHICS
fascicolo: 2, volume: 19, anno: 1999,
pagine: 453 - 471
SICI:
0271-5333(199903/04)19:2<453:FCOTLR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL NODULAR HYPERPLASIA; HEPATOCELLULAR-CARCINOMA; MR APPEARANCE; CT; HEPATOMA; VARIANT; LESIONS; CHOLANGIOCARCINOMA; TRANSPLANTATION; HEPATECTOMY;
Keywords:
liver neoplasms; liver neoplasms, MR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: McLarney, JK Armedton,ces Inst Pathol, Dept Radiol Pathol, 14th & Alaska Sts,NW, Washing Armed Forces Inst Pathol 14th & Alaska Sts,NW Washington DC USA 20306
Citazione:
J.K. McLarney et al., "Fibrolamellar carcinoma of the liver: Radiologic-pathologic correlation", RADIOGRAPHI, 19(2), 1999, pp. 453-471

Abstract

Fibrolamellar carcinoma is a malignant hepatocellular tumor with distinct clinical and pathologic differences from hepatocellular carcinoma, It differs from hepatocellular carcinoma in demographics, condition of the affectedliver, tumor markers, and prognosis. Fibrolamellar carcinoma characteristically manifests as a large hepatic mass in adolescents or young adults (without gender predominance). Cirrhosis; elevated a-fetoprotein levels; and typical risk factors for hepatocellular carcinoma such as viral hepatitis, alcohol abuse, and metabolic disease are typically absent. Fibrolamellar carcinoma is characterized pathologically by cords of tumor cells surrounded byabundant collagenous fibrous tissue arranged in a parallel or lamellar distribution. Fibrotic lamellae often coalesce to form a central scar. Fibrolamellar carcinoma characteristically appears on radiologic images as a lobulated heterogeneous mass with a central scar in an otherwise normal liver. Radiologic evidence of cirrhosis, vascular invasion, or multifocal disease-findings typical of hepatocellular carcinoma-is uncommon in fibrolamellar carcinoma. Imaging features of fibrolamellar carcinoma overlap with those of other scar-producing lesions including focal nodular hyperplasia (FNH), hepatocellular adenoma and carcinoma, hemangioma, metastases, and cholangiocarcinoma. FNH, in particular, may simulate fibrolamellar carcinoma, since both have similar demographic and clinical characteristics. Because some believe that radiologic diagnosis of FNH is possible, it is important to understand the imaging appearance of fibrolamellar carcinoma to avoid misdiagnosing this malignant tumor as a FNH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:02:47