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Titolo:
Is gliadin mispresented to the immune system in coeliac disease? A hypothesis
Autore:
Biagi, F; Zimmer, KP; Thomas, PD; Ellis, HJ; Ciclitira, PJ;
Indirizzi:
StE1homas Hosp, Rayne Inst, Dept Gastroenterol, Gastroentrol Unit, London S St Thomas Hosp London England SE1 7EH terol, Gastroentrol Unit, London S Univ Munster, Childrens Hosp, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 rens Hosp, D-48149 Munster, Germany
Titolo Testata:
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
fascicolo: 2, volume: 92, anno: 1999,
pagine: 119 - 122
SICI:
1460-2725(199902)92:2<119:IGMTTI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL RESPONSES; CELIAC-DISEASE; HLA-DR; PERIPHERAL-BLOOD; ANTIGEN; MUCOSA; EXPRESSION; ANTIBODY; LYMPHOCYTES; ENTEROCYTES;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Ciclitira, PJ StPalaces Hosp, Rayne Inst, Dept Gastroenterol, GastroentrolUnit, Lambeth St Thomas Hosp Lambeth Palace Rd London England SE1 7EH eth
Citazione:
F. Biagi et al., "Is gliadin mispresented to the immune system in coeliac disease? A hypothesis", QJM-MON J A, 92(2), 1999, pp. 119-122

Abstract

The primary pathogenic trigger in coeliac disease (CD) is still unknown. We present the hypothesis that in Co the enterocytes could metabolize gliadin through an immunogenic pathway instead of a tolerogenic one. The result of this abnormal presentation of gliadin to the immune system would be the activation of lamina propria T cells, followed by the onset of enteropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:09:36