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Titolo:
Protein structure comparison using iterated double dynamic programming
Autore:
Taylor, WR;
Indirizzi:
Natl Inst Med Res, Div Math Biol, London NW7 1AA, England Natl Inst Med Res London England NW7 1AA h Biol, London NW7 1AA, England
Titolo Testata:
PROTEIN SCIENCE
fascicolo: 3, volume: 8, anno: 1999,
pagine: 654 - 665
SICI:
0961-8368(199903)8:3<654:PSCUID>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRUCTURE ALIGNMENT; 2 PROTEINS; IDENTIFICATION; SEQUENCE; CHAINS;
Keywords:
protein structure comparison; root-mean-square deviation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, WR Natlndnst Med Res, Div Math Biol, Ridgeway,Mill Hill, London NW7 1AA, Engla Natl Inst Med Res Ridgeway,Mill Hill London England NW7 1AA la
Citazione:
W.R. Taylor, "Protein structure comparison using iterated double dynamic programming", PROTEIN SCI, 8(3), 1999, pp. 654-665

Abstract

A protein structure comparison method is described that allows the generation of large populations of high-scoring alternate alignments. This was achieved by incorporating a random element into an iterative double dynamic programming algorithm. The maximum scores from repeated comparisons of a pairof structures converged on a value that was taken as the global maximum. This lay 15% over the score obtained from the single fixed (unrandomized) calculation. The effect of the gap penalty was observed through the shift of the alignment populations, characterized by their alignment length and root-mean-square deviation (RMSD). The best (lowest RMSD) values found in thesepopulations provided a base-line against which other methods were compared.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:15:59