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Titolo:
Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable?
Autore:
Hunziker, EB;
Indirizzi:
Univ Bern, ME Muller Inst Biomech, CH-3010 Bern, Switzerland Univ Bern Bern Switzerland CH-3010 st Biomech, CH-3010 Bern, Switzerland
Titolo Testata:
OSTEOARTHRITIS AND CARTILAGE
fascicolo: 1, volume: 7, anno: 1999,
pagine: 15 - 28
SICI:
1063-4584(199901)7:1<15:ACRATI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FULL-THICKNESS DEFECTS; AUTOLOGOUS CHONDROCYTE TRANSPLANTATION; CONTINUOUS PASSIVE MOTION; MEDIAL FEMORAL CONDYLE; OSTEOCHONDRAL DEFECTS; RABBIT KNEE; PERICHONDRIAL GRAFT; JOINT; REGENERATION; SYSTEM;
Keywords:
articular; cartilage repair; full-thickness; partial-thickness; defects;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
104
Recensione:
Indirizzi per estratti:
Indirizzo: Hunziker, EB Univerland ME Muller Inst Biomech, Murtenstr 35,POB 30, CH-3010 Bern, Switz Univ Bern Murtenstr 35,POB 30 Bern Switzerland CH-3010 Switz
Citazione:
E.B. Hunziker, "Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable?", OSTEO CART, 7(1), 1999, pp. 15-28

Abstract

This article reviews the experimental and clinical strategies currently inuse or under development for the treatment of articular cartilage lesions. The vast majority of protocols under investigation pertain to the treatment of full-thickness defects (i.e., those which penetrate the subchondral bone and trabecular-bone spaces) rather than partial-thickness ones (i.e., those which are confined to the substance of articular cartilage tissue itself). This bias probably reflects the circumstance that partial-thickness defects do not heal spontaneously whereas full-thickness ones below a criticalsize do, albeit transiently. And it is, of course, a seemingly easier taskto manipulate a process which is readily set in train than it is to overcome an induction-problem which Nature herself has not solved. Indeed, the reasons for this inert state of partial-thickness defects have only recently been elucidated, and these are briefly discussed. However, the main body ofthis review deals with the various transplantation concepts implemented for the repair of full-thickness defects. These fall into two broad categories: tissue-based (entailing the grafting of perichondrial, periosteal, cartilage or bone-cartilage material) and cell-based (utilizing chondroblasts, chondrocytes, periochondrial cells or mesenchymal stem cells). Cell-based systems are further subdivided according to whether cells are transplanted within a matrix (biodegradable, non-biodegradable or synthetic) or free in suspension. Thus far, the application of cell suspensions has always been combined with the grafting of a periosteal flap. The strengths and weaknesses of each concept are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 23:29:22