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Titolo:
Cerebral neurons express interleukin-6 after transient forebrain ischemia in gerbils
Autore:
Suzuki, S; Tanaka, K; Nagata, E; Ito, D; Dembo, T; Fukuuchi, Y;
Indirizzi:
Keio Univ, Sch Med, Dept Neurol, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 Neurol, Shinjuku Ku, Tokyo 1608582, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 262, anno: 1999,
pagine: 117 - 120
SICI:
0304-3940(19990305)262:2<117:CNEIAT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; RAT-BRAIN; LOCALIZATION; INCREASES; ALPHA; IL-6;
Keywords:
cerebral cortex; gerbil; ischemia; hippocampus; immunohistochemistry; interleukin-6; neuron; Western blot;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, S Keio,Univ, Sch Med, Dept Neurol, Shinjuku Ku, 35 Shinaomachi, Tokyo 1608582 Keio Univ 35 Shinaomachi Tokyo Japan 1608582 chi, Tokyo 1608582
Citazione:
S. Suzuki et al., "Cerebral neurons express interleukin-6 after transient forebrain ischemia in gerbils", NEUROSCI L, 262(2), 1999, pp. 117-120

Abstract

Markedly increased interleukin-6 (IL-6) mRNA levels occur in experimental cerebral ischemia, although the protein production and cellular sources of IL-6 remain unclear. We examined the cellular localization of IL-6 protein in gerbil brain following transient forebrain ischemia employing immunohistochemistry and Western blot analysis. The ischemia/recirculation groups revealed distinct IL-6 immunoreactivity predominantly in cortical and hippocampal neurons after 3 hours to 3 days recirculation. At 12 h recirculation, the IL-6 expression declined specifically in the hippocampus CA1. Microglia,but not activated astrocytes, also expressed IL-6 immunoreactivity. The sham group showed no apparent immunoreactivity. IL-6 protein may thus be expressed mainly in neurons following transient forebrain ischemia. Its transient decline in the CAI at 12 h recirculation could reflect the specific vulnerability of this region. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:42:41