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Titolo:
Negative immunoregulatory effects of antidepressants: Inhibition of interferon-gamma and stimulation of interleukin-10 secretion
Autore:
Maes, M; Song, C; Lin, AH; Bonaccorso, S; Kenis, G; De Jongh, R; Bosmans, E; Scharpe, S;
Indirizzi:
Univ60ntwerp, Clin Res Ctr Mental Hlth, Dept Psychiat, AZ Stuivenberg, B-20 Univ Antwerp Antwerp Belgium B-2060 Dept Psychiat, AZ Stuivenberg, B-20 Vanderbilt Univ, Dept Psychiat, Nashville, TN USA Vanderbilt Univ Nashville TN USA Univ, Dept Psychiat, Nashville, TN USA Univ Ottawa, Life Sci Res Ctr, Ottawa, ON K1N 6N5, Canada Univ Ottawa Ottawa ON Canada K1N 6N5 Res Ctr, Ottawa, ON K1N 6N5, Canada Univ Antwerp, Dept Med Biochem, Edegem, Belgium Univ Antwerp Edegem Belgium Antwerp, Dept Med Biochem, Edegem, Belgium Univ Rome La Sapienza, Dept Psychiat, Rome, Italy Univ Rome La Sapienza Rome Italy a Sapienza, Dept Psychiat, Rome, Italy Eurogenet Tessenderlo, Tessenderlo, Belgium Eurogenet Tessenderlo Tessenderlo Belgium enderlo, Tessenderlo, Belgium AZ Oost Limburg, Dept Anesthesiol, Genk, Belgium AZ Oost Limburg Genk Belgium t Limburg, Dept Anesthesiol, Genk, Belgium
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 20, anno: 1999,
pagine: 370 - 379
SICI:
0893-133X(199904)20:4<370:NIEOAI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; IV PHOSPHODIESTERASE INHIBITOR; MAJOR DEPRESSIVE DISORDER; CELL-MEDIATED-IMMUNITY; T-LYMPHOCYTE FUNCTION; ACUTE-PHASE PROTEINS; TNF-ALPHA; IFN-GAMMA; SEROTONIN ANTAGONISTS; SOLUBLE INTERLEUKIN-2;
Keywords:
cytokines; depression; interferon-gamma; interleukin-10; antidepressants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Maes, M UnivLangeerp, Clin Res Ctr Mental Hlth, Dept Psychiat, AZ Stuivenberg, 267 Univ Antwerp 267 Lange Beeldekenstr Antwerp Belgium B-2060 g, 267
Citazione:
M. Maes et al., "Negative immunoregulatory effects of antidepressants: Inhibition of interferon-gamma and stimulation of interleukin-10 secretion", NEUROPSYCH, 20(4), 1999, pp. 370-379

Abstract

There is now some evidence that major depression is accompanied by activation of the inflammatory response system. There is also some evidence that antidepressants may suppress the release of cytokines, such as interleukin-1beta (IL-2 beta) and IL-6 by activated monocytes and IL-2 and interferon-gamma (IFN gamma) by activated T cells. This study was carried out to examine the effects of clomipramine, sertraline, and trazodone on the stimulated production of IFN gamma, a pro-inflammatory cytokine, and IL-10, a negativeimmunoregulatory cytokine. Whole blood of nine healthy volunteers was stimulated with PHA, 5 mu g/mL and LPS, 25 mu g/mL for 72 hr with and without incubation with clomipramine, 10(-6) and 10(-9) M, sertraline, 10(-6) and 10(-8) M, and trazodone, 10(-6) and 10(-8) M. All three anti-depressants significantly reduced IFN gamma secretion, whereas clomipramine and sertraline significantly increased IL-10 secretion in culture supernatant. All three antidepressants significantly reduced the IFN gamma/IL-10 ratio. The resultssuggest that antidepressants, at concentrations in the therapeutical range, have negative immunoregulatory effects through inhibition of IFN gamma and stimulation of IL-10 release. [Neuropsychopharmacology 20:370-379, 1999] (C) 1999 American College of Neuropsychology. Published by Elsevier ScienceInc.

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Documento generato il 14/07/20 alle ore 13:17:01