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Titolo:
Environmental influences on cognitive decline in aged rats
Autore:
Winocur, G;
Indirizzi:
Baycrest Ctr Geriatr Care, Rotman Res Inst, Toronto, ON, Canada Baycrest Ctr Geriatr Care Toronto ON Canada es Inst, Toronto, ON, Canada Trent Univ, Dept Psychol, Peterborough, ON K9J 7B8, Canada Trent Univ Peterborough ON Canada K9J 7B8 eterborough, ON K9J 7B8, Canada Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada Univ Toronto Toronto ON Canada M5S 1A1 ychol, Toronto, ON M5S 1A1, Canada Univ Toronto, Dept Psychiat, Toronto, ON M5S 1A1, Canada Univ Toronto Toronto ON Canada M5S 1A1 chiat, Toronto, ON M5S 1A1, Canada
Titolo Testata:
NEUROBIOLOGY OF AGING
fascicolo: 6, volume: 19, anno: 1998,
pagine: 589 - 597
SICI:
0197-4580(199811/12)19:6<589:EIOCDI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
OLD-PEOPLE; PREFRONTAL CORTEX; MEMORY PERFORMANCE; TEMPORAL-LOBE; YOUNG-RATS; ADULT-RATS; BRAIN; LESIONS; HIPPOCAMPAL; BEHAVIOR;
Keywords:
aging; cognitive function; environmental influences;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Winocur, G HebrewIsraelJerusalem, Dept Psychol, Mt Scopus Campus, IL-91905Jerusalem, Hebrew Univ Jerusalem Mt Scopus Campus Jerusalem Israel IL-91905
Citazione:
G. Winocur, "Environmental influences on cognitive decline in aged rats", NEUROBIOL A, 19(6), 1998, pp. 589-597

Abstract

Two experiments are reported in which young and old rats, housed in an impoverished (IE), enriched, (EE), or standard (SE), environment, were tested on a series of complex, blind-alley mazes. In Experiment 1, 3-months exposure to IE exacerbated age differences in maze performance, relative to the differences between young and old rats in EE and SE. Old rats in the EE and SE conditions did nor differ from each other. In Experiment 2, rats were raised for an additional ? months in tither IE or EE before further maze testing. The main findings were that the maze performance of old rats, transferred from IE to EE, improved significantly, whereas the performance of old rats, transferred from SE or EE to IE, declined. These results indicated that the: deleterious effects of an impoverished environment on learning and memory are, at least partly, reversible, and that experience in a stimulating environment can protect old rats from the adverse effects of relocation to a deprived environment. Taken together, the results highlight the impact of environmental influences on cognitive function in old age, and emphasizethe need to consider nonbiological factors in understanding the process ofaging. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:43:45