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Titolo:
Follicular fluid levels of vascular endothelial growth factor - Are they predictive markers for ovarian hyperstimulation syndrome
Autore:
Geva, E; Amit, A; Lessing, JB; Lerner-Geva, L; Daniel, Y; Yovel, I; Azem, F; Barak, V;
Indirizzi:
Lisetatern Hosp, Tel Aviv Sourasky Med Ctr, Sara Racine IVF Unit, Dept Obst Lis Matern Hosp Tel Aviv Israel ed Ctr, Sara Racine IVF Unit, Dept Obst TelL-69978niv, Sackler Fac Med, Chaim Sheba Med Ctr, Dept Clin Epidemiol, I Tel Aviv Univ Tel Aviv Israel IL-69978 a Med Ctr, Dept Clin Epidemiol, I Hebrew Univ Jerusalem, Hadassah Med Ctr, Immunol Lab Tumor Diag, Jerusalem, Hebrew Univ Jerusalem Jerusalem Israel munol Lab Tumor Diag, Jerusalem,
Titolo Testata:
JOURNAL OF REPRODUCTIVE MEDICINE
fascicolo: 2, volume: 44, anno: 1999,
pagine: 91 - 96
SICI:
0024-7758(199902)44:2<91:FFLOVE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO FERTILIZATION; TYROSINE KINASE; RISK-FACTORS; FACTOR VEGF; EXPRESSION; RECEPTOR; INTERLEUKIN-2; ANGIOGENESIS; ENDOMETRIUM; CELLS;
Keywords:
ovarian hyperstimulation syndrome; endothelium; vascular; fertilization in vitro; vascular endothelial growth factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Geva, E Tel Aviv Sourasky Med Ctr, Sara Racine IVF Unit, 6 Weizman St, IL-64239 Tel Tel Aviv Sourasky Med Ctr 6 Weizman St Tel Aviv Israel IL-64239 l
Citazione:
E. Geva et al., "Follicular fluid levels of vascular endothelial growth factor - Are they predictive markers for ovarian hyperstimulation syndrome", J REPRO MED, 44(2), 1999, pp. 91-96

Abstract

OBJECTIVE: To determine the possible predictive role of vascular endothelial growth factor (VEGF) levels in the follicular fluid (FF) at the time of oocyte retrieval in the development of ovarian hyperstimulation syndrome (OHSS) and its possible origin. STUDY DESIGN: FF was obtained from 174 high-responder patients at the timeof oocyte retrieval. The study group comprised 16 high-responder patients who developed early, severe OHSS and from whom serum and peritoneal fluid (PF) were obtained during the active phase of the syndrome. These women werecompared to 16 high-responder patients who did not develop OHSS. An additional control group comprised 16 low-responder patients who also did not develop OHSS. The FF, serum and PF samples were tested for VEGF by enzyme-lined immunosorbent assay. RESULTS: No differences in the FF VEGF levels were found among the OHSS group (1,742.3 +/- 522.4 pg/mL), the high-responder group that did not develop OHSS (1,802.0 +/- 584.3 pg/mL) and the low-responder group (1,686.7 +/- 374.2 pg/mL). In the OHSS group, no differences were found between the serumand PF VEGF levels (247.3 +/- 31.4 and 642.9 +/- 328.3 pg/mL, respectively). No correlation runs found between the FF concentrations of VEGF and the mean serum 17-beta estradiol levels or number of oocytes retrieved. CONCLUSION: We conclude that preovulatory FF levels should nor serve as a possible predictive factor development of OHSS. The increased capillary permeability found in OHSS may be due to ifs systemic effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:50:47