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Titolo:
Effect of D-002 on the pre-ulcerative phase of carrageenan-induced coloniculceration in the guinea-pig
Autore:
Noa, M; Mas, R;
Indirizzi:
Natl Ctr Sci Res, Histol Lab, Ctr Nat Prod, Havana 6880, Cuba Natl Ctr SciRes Havana Cuba 6880 l Lab, Ctr Nat Prod, Havana 6880, Cuba
Titolo Testata:
JOURNAL OF PHARMACY AND PHARMACOLOGY
fascicolo: 5, volume: 50, anno: 1998,
pagine: 549 - 553
SICI:
0022-3573(199805)50:5<549:EODOTP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; EXPERIMENTAL COLITIS; INJURY; RATS; INTESTINE; BEESWAX; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Noa, M NatlHavanaci Res, Histol Lab, Ctr Nat Prod, Post Box 6990,25 Ave & 158 St, Natl Ctr Sci Res Post Box 6990,25 Ave & 158 St Havana Cuba 6880 t,
Citazione:
M. Noa e R. Mas, "Effect of D-002 on the pre-ulcerative phase of carrageenan-induced coloniculceration in the guinea-pig", J PHARM PHA, 50(5), 1998, pp. 549-553

Abstract

D-002 is a natural mixture of higher aliphatic primary alcohols, isolated and purified from beeswax which has anti-inflammatory properties, reduces leukotrienes (LTB4) and thromboxane B-2 (TXB2) in exudated carrageenan-induced pleurisy, and has anti-ulcer activity in different experimental models. This study was conducted to determine the effect of D-002 on the pre-ulcerative phase of carrageenan-induced colonic ulceration in guinea-pigs. Animals were randomly distributed among a negative control, a positive control group treated with the vehicle Tween 20 in H2O and two experimental groups receiving D-002 at 25 and 50 mg kg(-1). All treated animals received degraded carrageenan for three days for induction of colonic ulceration. Significant reductions in wet weight, wall thickness, counts of infiltrating polymorphonuclear neutrophils and of macrophages, and histological index were observed in colonic mucosa of D-002-treated animals compared with controls. It is concluded that D-002 has a protective effect on the pre-ulcerative phase of carrageenan-induced colonic ulceration in the guinea-pig.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 11:20:10