Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dietary nucleotide supplementation raises erythrocyte 2,3-diphosphoglycerate concentration in neonatal rats
Autore:
Scopesi, F; Verkeste, CM; Paola, D; Gazzolo, D; Pronzato, MA; Bruschettini, PL; Marinari, UM;
Indirizzi:
Univtalyoa, Ist Giannina Gaslini Direz Sci, Dept Neonatol, I-16147 Genoa, I Univ Genoa Genoa Italy I-16147 irez Sci, Dept Neonatol, I-16147 Genoa, I Univ Maastricht, Maastricht, Netherlands Univ Maastricht Maastricht Netherlands stricht, Maastricht, Netherlands
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 3, volume: 129, anno: 1999,
pagine: 662 - 665
SICI:
0022-3166(199903)129:3<662:DNSRE2>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RED-CELL 2,3-DIPHOSPHOGLYCERATE; OXYGEN-TRANSPORT; NEWBORN RATS; INFANTS; TERM; ADAPTATION; AFFINITY; GROWTH; ACID; AGE;
Keywords:
artificial feeding; nucleotides; erythrocyte; oxygen affinity; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Scopesi, F Univaslini, Ist Giannina Gaslini Direz Sci, Dept Neonatol, Largo Gerolamo G Univ Genoa Largo Gerolamo Gaslini 5 Genoa Italy I-16147 lamo G
Citazione:
F. Scopesi et al., "Dietary nucleotide supplementation raises erythrocyte 2,3-diphosphoglycerate concentration in neonatal rats", J NUTR, 129(3), 1999, pp. 662-665

Abstract

The present study was designed to test if dietary intake of nucleotides increases erythrocyte 2,3-diphosphoglycerate (2,3-DPG) in neonatal rats. To this end, rat pups were fed a nucleotide-supplemented formula (S, n = 14) from d 9 until d 16 after birth. The results were compared with those obtained from a group of breast-fed pups (C, n = 14) and a group of pups artificially fed with nucleotide-free formula (NS, n = 14), Neonatal weight, 2,3-DPGconcentration, hematocrit (Hct) and hemoglobin concentration (Hb) were determined before the experiment (d 9) and after 7 d of treatment (d 16). In all groups, 2,3-DPG concentration was greater at d 16 than d 9, and the increase was greater in the S group than in the NS group. Alterations in neonatal weight, Hct and Hb concentration did not differ among the groups. On d 16 the 2,3-DPG/Hb ratio, reflecting the affinity of hemoglobin for oxygen, was significantly higher in the C and S groups than in the NS group. We conclude that in neonatal rats, dietary nucleotides increase erythrocyte 2,3-DPG concentration. Studies need to be conducted in humans to assess the effect of this increase on both neonatal peripheral hemodynamics and metabolism in this species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:02:15