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Titolo:
Toward a role of dendritic cells in the germinal center reaction: Triggering of B cell proliferation and isotype switching
Autore:
Dubois, B; Barthelemy, C; Durand, I; Liu, YJ; Caux, C; Briere, F;
Indirizzi:
Schering Plough, Lab Immunol Res, F-69571 Dardilly, France Schering Plough Dardilly France F-69571 ol Res, F-69571 Dardilly, France DNAX Res Inst Mol & Cellular Biol Inc, Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc Palo Alto CA USA 94304 CA 94304 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 6, volume: 162, anno: 1999,
pagine: 3428 - 3436
SICI:
0022-1767(19990315)162:6<3428:TARODC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELLS; CD40 LIGAND; LANGERHANS CELLS; LYMPHOCYTES-B; BONE-MARROW; SUBCAPSULAR SINUS; PLASMA-CELLS; IN-VITRO; GROWTH; INTERLEUKIN-10;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Briere, F Scheringly,ough, Lab Immunol Res, 27 Chemin Peupliers,BP 11, F-69571 Dardil Schering Plough 27 Chemin Peupliers,BP 11 Dardilly France F-69571
Citazione:
B. Dubois et al., "Toward a role of dendritic cells in the germinal center reaction: Triggering of B cell proliferation and isotype switching", J IMMUNOL, 162(6), 1999, pp. 3428-3436

Abstract

We have reported previously that in vitro generated dendritic cells (DC) can directly regulate B cell responses. Recently, germinal center DC (GCDC) were identified within B cell follicles, Due to their particular localization, we have tested in the present study whether GCDC could contribute to key events characteristic of the GC reaction, Our present results demonstratethat 1) ex vivo GCDC induce a dramatic GC B cell expansion upon CD40 and IL-2 activation and drive plasma cell differentiation, 2) this property is shared by GCDC and blood DC, but not by Langerhans cells, 3) IL-12 production by GCDC is critical in GC B cell expansion and differentiation, and 4) importantly, GCDC also induce IL-10-independent isotype switching toward IgG1, These observations support the novel concept that GCDC directly contribute to the germinal center reaction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 08:23:51