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Titolo:
Tyr-Ala-Hexarelin, a synthetic octapeptide, possesses the same endocrine activities of hexarelin and GHRP-2 in humans
Autore:
Arvat, E; Di Vito, L; Lanfranco, F; Broglio, F; Giordano, R; Benso, A; Muccioli, GP; Deghenghi, R; Ghigo, E;
Indirizzi:
Univ Turin, Dipartimento Med Interna, Div Endocrinol, Turin, Italy Univ Turin Turin Italy imento Med Interna, Div Endocrinol, Turin, Italy Univlyurin, Dipartimento Farmacol & Med Forense, Div Endocrinol, Turin, Ita Univ Turin Turin Italy rmacol & Med Forense, Div Endocrinol, Turin, Ita Europeptides, Argenteuil, France Europeptides Argenteuil FranceEuropeptides, Argenteuil, France
Titolo Testata:
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
fascicolo: 2, volume: 22, anno: 1999,
pagine: 91 - 97
SICI:
0391-4097(199902)22:2<91:TASOPT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING PEPTIDE; (GHRP-6)-INDUCED GH SECRETION; GROWTH-HORMONE; HYPOTHALAMIC MEMBRANES; ANTERIOR-PITUITARY; SECRETAGOGUE; HEXAPEPTIDE; CORTISOL; RAT; PROLACTIN;
Keywords:
Tyr-Ala-Hexarelin; hexarelin; GHRP-2; GH; PRL; ACTH; cortisol; humans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Ghigo, E Osped Molinette, Div Endocrinol, Cso Dogliotti 14, I-10126 Turin,Italy Osped Molinette Cso Dogliotti 14 Turin Italy I-10126 urin, Italy
Citazione:
E. Arvat et al., "Tyr-Ala-Hexarelin, a synthetic octapeptide, possesses the same endocrine activities of hexarelin and GHRP-2 in humans", J ENDOC INV, 22(2), 1999, pp. 91-97

Abstract

Hexarelin (HEX) and GHRP-2 are two synthetic hexapeptides, superanalogs ofGHRP-6, belonging to GH secretagogue (GHS) family. GHS act via specific receptors at both the pituitary and the hypothalamic level to stimulate GH release both in animals and in humans. However, GHS also possess significant PRL- and ACTH/cortisol-releasing activity. Tyr-Ala-HEX as well as Tyr-Ala-GHRP-6 are, in turn, synthetic octapeptides generally used to perform binding studies because of their easy iodination. However, their endocrine activities have never been studied in humans. To clarify the endocrine activitiesof Tyr-Ala-HEX, in 7 young adult volunteers we compared the effects of themaximal effective dose of HEX (2.0 mu g/kg iv) or GHRP-2 (2.0 mu g/kg iv) with the same one of Tyr-Ala-HEX on GH, PRL, ACTH and cortisol levels. Basal GH, PRL, ACTH and cortisol levels in all testing sessions were similar. The administration of placebo did not modify hormonal levels. HEX and GHRP-2administration induced the well known strong GH response (Cmax, mean+/-SE:77.3+/-6.0 and 74.1 +/- 12.1 mu g/l; AUG, mean+/-SE: 2596.7+/-251.1 and 2480.0+/-343.6 mu g*min/l). These responses were similar to that induced by Tyr-Ala-HEX (63.7+/-18.5 mu g/l; 1986.6+/-622.4 mu g*min/l). Moreover, HEX, GHRP-2 and Tyr-Ala-HEX had the same significant stimulatory effect on PRL (14.9+/-2.5, 12.3+/-2.0 and 10.0+/-1.5 mu g/l; 497.8+/-61.8, 480.4+/-66.9 and 415.8+/-58.5 mu g*min/l), ACTH (48.0+/-10.1, 51.4+/-10.6 and 44.9+/-12.2 pg/ml; 1531.6+/-235.7, 1586.7+/-277.0 and 1338.1+/-164.5 pg*min/ml) and cortisol (179.9+/-10.0, 181.2+/-14.1 and 149.7+/-20.1 mu g/l; 8465.0+/-406.6, 8689.2+/-788.1 and 6295.2+/-797.0 mu g*min/l). Also the mean T-max of the endocrine responses to HEX, GHRP-2 and Tyr-Ala-HEX were similar. In conclusion, the present results demonstrate that in humans Tyr-Ala-HEX is a GH secretagogue as potent as HEX and GHRP-2, two GHRP-6 superanalogs. Tyr-Ala-HEX also shares with HEX and GHRP-2 the same PRL- ACTH- and cortisol-releasing activity. (C) 1999, Editrice Kurtis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 19:08:32