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Titolo:
Increased intracranial pressure after coronal suturectomy in craniosynostotic rabbits
Autore:
Mooney, MP; Fellows-Mayle, W; Losken, HW; Dechant, J; Burrows, AM; Smith, TD; Cooper, GM; Pollack, I; Siegel, MI;
Indirizzi:
Univ Pittsburgh, Dept Anat & Histol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Histol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 ol Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 pt Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Anthropol, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 thropol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Orthodont, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 thodont, Pittsburgh, PA 15261 USA Slippery Rock Univ, Dept Phys Therapy, Slippery Rock, PA 16057 USA Slippery Rock Univ Slippery Rock PA USA 16057 Slippery Rock, PA 16057 USA
Titolo Testata:
JOURNAL OF CRANIOFACIAL SURGERY
fascicolo: 2, volume: 10, anno: 1999,
pagine: 104 - 110
SICI:
1049-2275(199903)10:2<104:IIPACS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; TRANSCRANIAL DOPPLER SONOGRAPHY; SYNDROMIC CRANIOSYNOSTOSIS; CRANIAL VAULT; SYNOSTOSIS; HYPERTENSION; GROWTH; CRANIOSTENOSIS; DECOMPRESSION; MANAGEMENT;
Keywords:
intracranial pressure; rabbits; nonsyndromic; craniosynostosis; neurocapsule;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Mooney, MP UnivAPittsburgh, Dept Anat & Histol, 619 Salk Hall, Pittsburgh,PA 15261 US Univ Pittsburgh 619 Salk Hall Pittsburgh PA USA 15261 15261 US
Citazione:
M.P. Mooney et al., "Increased intracranial pressure after coronal suturectomy in craniosynostotic rabbits", J CRANIOF S, 10(2), 1999, pp. 104-110

Abstract

It has been suggested that the complications associated with intracranial hypertension in cranio-synostotic infants may be managed with surgical release of the synostosed sutures. However, both postoperative increases and decreases in intracranial pressure (ICP) have been reported in heterogeneous samples of infants with syndromic and nonsyndromic craniosynostoses. The present study tvas designed to describe longitudinal changes in ICP in a homogeneous sample of rabbits with uncorrected and corrected familial coronal suture synostosis and compare them with age-matched normal control rabbits. Fifty-three rabbits were divided into three groups: normal rabbits (n = 28), rabbits with uncorrected bilateral coronal suture synostosis (n = 9), andrabbits with bilateral coronal suture synostosis with coronal suturectomy at 25 days of age (n = 16). ICP was measured at 25 and 42 days of age usinga Codman epidural microtransducer. Results revealed that rabbits with uncorrected craniosynostosis had significantly (P < 0.05) higher ICP at 25 daysof age than normal control rabbits by approximately 86%. However, by 42 days of age, ICP in normal rabbits increased by 75%, whereas ICP in rabbits with uncorrected craniosynostosis decreased by 69% over the same time. Synostotic rabbits with coronal suturectomy showed a 50% decrease in ICP immediately after surgical release and then followed the normal, age-related ICP pattern, which significantly increased by 75% at 42 days of age. Results suggest that, in the rabbit model, the postsuturectomy rise in ICP may simply be normal, age-related changes, although a longer follow-up will be needed to determine the recurrence of pathological ICP. Possible multifactorial explanations for intracranial decompression and compensation in the craniosynostotic rabbit model are also discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 22:57:18