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Titolo:
Studies of body composition and fat distribution in HIV-infected and control subjects
Autore:
Kotler, DP; Rosenbaum, K; Wang, J; Pierson, RN;
Indirizzi:
Columbianaliv, Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Gastrointesti Columbia Univ New York NY USA 10025 kes Roosevelt Hosp Ctr, Gastrointesti Columbia Univ, Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Dept Med,Body Columbia Univ New York NY USA 10025 kes Roosevelt Hosp Ctr, Dept Med,Body
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
fascicolo: 3, volume: 20, anno: 1999,
pagine: 228 - 237
SICI:
1525-4135(19990301)20:3<228:SOBCAF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; VISCERAL ADIPOSE-TISSUE; DEPENDENT DIABETES-MELLITUS; PITUITARY-ADRENAL AXIS; ANTHROPOMETRIC MEASUREMENTS; COMPUTED-TOMOGRAPHY; WAIST CIRCUMFERENCE; CORTISOL SECRETION; MASS INDEX; MEN;
Keywords:
nutritional assessment; body composition; fat distribution; HIV infection; antiretroviral agents; protease inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Kotler, DP Columbianaliv, Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Gastrointesti Columbia Univ S&R 1301,1111 Amsterdam Ave New York NY USA 10025
Citazione:
D.P. Kotler et al., "Studies of body composition and fat distribution in HIV-infected and control subjects", J ACQ IMM D, 20(3), 1999, pp. 228-237

Abstract

Objective: Recent studies have documented alterations in body fat distribution that have been associated with protease inhibitor therapy. We comparedbody composition, including measurements of fat distribution, in 96 HIV-infected subjects studied since January 1996 (current HIV), subjects seen prior to January 1996 (previous HIV), and healthy controls. Design: Retrospective cross-sectional studies of subjects matched by gender, race, age, and height. Methods: Body weight, height, body cell mass by whale-body counting of K-40 plus fat, fat-free mass, and body fat distribution by anthropometry were measured. Results: Current HIV men weighed more (p = .025) and had more body cell mass than previous HN men, but less than controls (p < .001). In women, the between group differences in fat were greater than the differences in body cell mass. Current and previous HIV study subjects had lower indices of subcutaneous and higher indices of visceral fat than controls. In current HIV subjects, body fat distribution was significantly associated with log plasmaHIV RNA content but not with antiretroviral or protease inhibitor usage, nor with CD4(+) lymphocyte counts. In 7 of 9 current HIV subjects studied, 24-hour urinary free cortisol excretion was abnormally high. Conclusions: Alterations in body fat distribution are a characteristic feature in HIV infection. The occurrence of increased visceral fat content anddecreased subcutaneous fat content preceded the era of combination antiretroviral therapy. The alteration in fat distribution may be affected by plasma HIV RNA content rather than antiretroviral or protease-inhibitor therapy. The body composition alterations might be associated with endogenous hypercortisolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:46:53