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Titolo:
Human papilloma virus (HPV) is possibly involved in laryngeal but not in lung carcinogenesis
Autore:
Gorgoulis, VG; Zacharatos, P; Kotsinas, A; Kyroudi, A; Rassidakis, AN;
Indirizzi:
Univ Athens, Sch Med, Dept Histol & Embryol, GR-10679 Athens, Greece Univ Athens Athens Greece GR-10679 ol & Embryol, GR-10679 Athens, Greece Univ Athens, Sch Med, Sotiria Hosp, Dept Pulm Med, GR-10679 Athens, GreeceUniv Athens Athens Greece GR-10679 ept Pulm Med, GR-10679 Athens, Greece Red Cross Hosp, Dept Pathol, Athens, Greece Red Cross Hosp Athens Greece ed Cross Hosp, Dept Pathol, Athens, Greece Royal Liverpool Univ Hosp, Dept Pathol, Liverpool, Merseyside, England Royal Liverpool Univ Hosp Liverpool Merseyside England rseyside, England
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 3, volume: 30, anno: 1999,
pagine: 274 - 283
SICI:
0046-8177(199903)30:3<274:HPV(IP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; SQUAMOUS-CELL CARCINOMAS; IN-SITU HYBRIDIZATION; P53 PROTEIN ACCUMULATION; INSITU DNA HYBRIDIZATION; VERRUCOUS CARCINOMA; CERVICAL SCRAPES; INFECTION; EXPRESSION; TYPE-16;
Keywords:
human papilloma virus; HPV; laryngeal carcinogenesis; lung carcinogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Gorgoulis, VG Antaiou 53,Lamprini,Ano Patisia, GR-11146 Athens, Greece Antaiou 53,Lamprini,Ano Patisia Athens Greece GR-11146 ece
Citazione:
V.G. Gorgoulis et al., "Human papilloma virus (HPV) is possibly involved in laryngeal but not in lung carcinogenesis", HUMAN PATH, 30(3), 1999, pp. 274-283

Abstract

Data on human papilloma virus (HPV) involvement in preneoplastic and neoplastic lesions of the larynx and lung are limited and conflicting. The presence of HPV was investigated in a series of laryngeal specimens and non-small cell lung carcinomas (NSCLCs). The laryngeal samples (154) comprised 14 cases with hyperplasia without dysplasia, 49 with dysplasia, and 91 squamouscell carcinomas (SqCCs). The NSCLCs included 31 SqCCs, 32 adenocarcinomas,and 5 undifferentiated large cell carcinomas. Furthermore, we examined, for HPV DNA sequences, 14 bronchial metaplastic squamous lesions located nextto cancerous areas. We used a sensitive nested polymerase chain reaction assay (NPCR), dot blotting, and in situ hybridization. The findings were correlated with clinicopathologic features of the patients. In the laryngeal specimens, NPCR analysis showed HPV DNA in 20 (13%) of the 154 specimens. Notably, 19 of 20 HPV-positive cases were carcinomas and only one was a mild dysplastic lesion. Typing of the carcinomas showed single HPV 6, 16, 18, and 33 infection in 1 (1.1%), 12 (13.2%), 2 (2.2%), and 1 (1.1%) samples, respectively, and HPV 6/33, 16/33, and 6/18 coinfection in three carcinomas. In situ hybridization findings were in agreement with PCR results, with the exception of two cases in which HPV 18 DNA was detected only by PCR. HPV was more frequently observed in heavy smokers than in patients with low dailycigarette consumption and nonsmokers (P = .03). There was no correlation between virus infection and gender grade, and lymph node status of the carcinomas. None of the NSCLCs or adjacent metaplastic squamous epithelium contained HPV DNA sequences. The presented data suggest a contributory role of HPV in late stages of laryngeal carcinogenesis, because all premalignant lesions were negative but one. This study does not support a potential role ofHPV in the development of NSCLCs. HUM PATHOL 30:274-283. Copyright (C) 1999 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 14:04:45