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Titolo:
Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies
Autore:
Halliwell, B;
Indirizzi:
Natl Univ Singapore, Dept Biochem, Singapore 119260, Singapore Natl Univ Singapore Singapore Singapore 119260 ngapore 119260, Singapore Univ6LX,don Kings Coll, Pharmacol Grp, Int Antioxidant Res Ctr, London SW3Univ London Kings Coll London England SW3 6LX xidant Res Ctr, London SW3
Titolo Testata:
FREE RADICAL RESEARCH
fascicolo: 6, volume: 29, anno: 1998,
pagine: 469 - 486
SICI:
1071-5762(1998)29:6<469:CODDBU>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMATOGRAPHY MASS-SPECTROMETRY; NITRIC-OXIDE; FREE-RADICALS; HYDROGEN-PEROXIDE; HYPOCHLOROUS ACID; QUANTITATIVE-DETERMINATION; ELECTROCHEMICAL DETECTION; LIPID-PEROXIDATION; GLUTATHIONE LEVELS; DEPENDENT DAMAGE;
Keywords:
oxidative DNA damage; hydroxyl radical; singlet oxygen; reactive oxygen/chlorine/nitrogen species; nitric oxide; peroxynitrite; antioxidants;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
141
Recensione:
Indirizzi per estratti:
Indirizzo: Halliwell, B Natl,Univ Singapore, Dept Biochem, 10 Kent Ridge Crescent, Singapore 119260 Natl Univ Singapore 10 Kent Ridge Crescent Singapore Singapore 119260
Citazione:
B. Halliwell, "Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies", FREE RAD RE, 29(6), 1998, pp. 469-486

Abstract

Damage to DNA by oxygen radicals and other reactive oxygen/nitrogen/chlorine species occurs in vivo despite the presence of multiple antioxidant defence and repair systems. Such damage is thought to make a significant contribution to the age-related development of cancer. Modulation of oxidative DNA damage by diet thus constitutes a "biomarker" putatively predictive of the effect of diet on cancer incidence, provided that DNA damage can be accurately quantitated by validated methods. Current issues addressed in Mis article include the problems of artifactual DNA oxidation during isolation andanalysis, the relative merits of different analytical methods, the advantages and disadvantages of relying on measurement of 8-hydroxydeoxyguanosine (8OHdG, 8-oxodG) as an index of oxidative DNA damage, and the limited data that are so far available on how diet can affect "steady-state" levels of oxidative DNA damage in humans. It appears that such damage tan be modulatedby vegetable intake, although the effects of vegetables may be mediated bycomponents different from the "classical" antioxidants vitamin C, alpha-tocopherol and beta-carotene.

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Documento generato il 25/11/20 alle ore 10:14:58