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Titolo:
IMPULSE-RESPONSE ANALYSIS OF BARORECEPTOR SENSITIVITY
Autore:
PANERAI RB; JAMES MA; POTTER JF;
Indirizzi:
UNIV LEICESTER,DEPT MED PHYS,LEICESTER ROYAL INFIRM,FAC MED,DIV MED PHYS LEICESTER LE1 5WW LEICS ENGLAND UNIV LEICESTER,GLENFIELD GEN HOSP,FAC MED,DIV MED ELDERLY LEICESTER LE3 9QP LEICS ENGLAND
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 4, volume: 41, anno: 1997,
pagine: 1866 - 1875
SICI:
0363-6135(1997)41:4<1866:IAOBS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE-VARIABILITY; BLOOD-PRESSURE; SPECTRAL-ANALYSIS; BAROREFLEX SENSITIVITY; CARDIOVASCULAR REGULATION; HYPERTENSIVE SUBJECTS; REFLEX SENSITIVITY; FLUCTUATIONS; SIGNALS; PERIOD;
Keywords:
BAROREFLEX; HYPERTENSION; BLOOD PRESSURE VARIABILITY; HEART RATE VARIABILITY; CARDIOVASCULAR REGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
R.B. Panerai et al., "IMPULSE-RESPONSE ANALYSIS OF BARORECEPTOR SENSITIVITY", American journal of physiology. Heart and circulatory physiology, 41(4), 1997, pp. 1866-1875

Abstract

The impulse response function (IRF) can express the dynamic relationship between systolic arterial pressure (SAP) and pulse interval (PI) and, consequently, represents an alternative method to assess baroreceptor sensitivity (BRS) in humans. Five normotensive and 13 hypertensivesubjects (age 68 +/- 5 yr, range 60-74 yr) were studied at rest in the supine position during baseline conditions and after injections of phenylephrine and sodium nitroprusside. SAP and PI signals were derivedfrom multiple 5-min noninvasive recordings of arterial blood pressure(Finapres) and electrocardiogram. Standard estimates of BRS were obtained by the slopes of transient changes in SAP and PI after the injection of phenylephrine and sodium nitroprusside (BRSPE and BRSSNP) and by spectral analysis (cr-index). impulse responses were obtained by theinverse Fourier transform of the transfer function between PI and SAP. The temporal pattern of the IRF was characterized by a main peak at t = 0, preceded by a ''trough'' at t = -1 s. A mathematical model of the baroreflex suggests that the peak value of IRF is linearly related to the BRS. The peak value and its smoothed version were shown to be significantly correlated to alpha, BRSPE, and BRSSNP and significantly reduced in the hypertensive group during the three stages of the protocol. We suggest that IRF might be the ideal method to assess BRS because it does not require any subjective preselection of data segments orspectral bands.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:30:33